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CAS 586966-54-3

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Pitavastatin tert-Butyl Ester

Description:
Pitavastatin tert-Butyl Ester, with the CAS number 586966-54-3, is a synthetic compound belonging to the class of statins, which are primarily used for lowering cholesterol levels in the blood. This compound is characterized by its ability to inhibit HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis. The tert-butyl ester group enhances its lipophilicity, potentially improving its absorption and bioavailability. Pitavastatin itself is known for its efficacy in reducing low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The compound typically exhibits good stability under physiological conditions and is metabolized primarily in the liver. Its pharmacokinetic profile includes a relatively long half-life, allowing for once-daily dosing. Additionally, it may have pleiotropic effects, contributing to cardiovascular health beyond cholesterol reduction. As with other statins, potential side effects may include muscle pain, liver enzyme elevation, and gastrointestinal disturbances, necessitating monitoring during therapy.
Formula:C29H32FNO4
InChI:InChI=1/C29H32FNO4/c1-29(2,3)35-26(34)17-22(33)16-21(32)14-15-24-27(18-10-12-20(30)13-11-18)23-6-4-5-7-25(23)31-28(24)19-8-9-19/h4-7,10-15,19,21-22,32-33H,8-9,16-17H2,1-3H3/b15-14+/t21-,22-/m1/s1
Synonyms:
  • tert-butyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
  • (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydrosy-6-heptenoic acid,1,1-dimethylethyl ester
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