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CAS 58880-22-1

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Leucomycin V, 9-deoxy-12,13-epoxy-12,13-dihydro-9-oxo-, 3,4B-diacetate, (12S,13S)-

Description:
Leucomycin V, with the CAS number 58880-22-1, is a macrolide antibiotic derived from the fermentation of the bacterium Streptomyces. It exhibits a complex structure characterized by a large lactone ring, which is typical of macrolides, and features specific functional groups such as acetyl groups that enhance its pharmacological properties. This compound is known for its antibacterial activity, particularly against Gram-positive bacteria, making it useful in treating various infections. The presence of the epoxy and keto groups in its structure contributes to its reactivity and biological activity. Leucomycin V is often studied for its potential applications in medicine, especially in the context of antibiotic resistance, as it may offer alternative therapeutic options. Its stereochemistry, indicated by the (12S,13S) configuration, plays a crucial role in its interaction with bacterial ribosomes, inhibiting protein synthesis. Overall, Leucomycin V represents an important class of antibiotics with significant implications for clinical use and research in antimicrobial agents.
Formula:C39H61NO16
InChI:InChI=1S/C39H61NO16/c1-19-15-25(13-14-41)35(36(48-10)29(52-23(5)42)17-30(45)49-20(2)16-28-27(54-28)12-11-26(19)44)56-38-33(46)32(40(8)9)34(21(3)51-38)55-31-18-39(7,47)37(22(4)50-31)53-24(6)43/h11-12,14,19-22,25,27-29,31-38,46-47H,13,15-18H2,1-10H3
InChI key:InChIKey=BSLHJKFVBDZBEO-UHFFFAOYSA-N
SMILES:O(C1C(OC)C(OC(C)=O)CC(=O)OC(C)CC2C(C=CC(=O)C(C)CC1CC=O)O2)C3C(O)C(N(C)C)C(OC4CC(C)(O)C(OC(C)=O)C(C)O4)C(C)O3
Synonyms:
  • Deltamycin A1
  • Leucomycin V, 9-deoxy-12,13-epoxy-12,13-dihydro-9-oxo-, 3,4B-diacetate, (12S,13S)-
  • 4,17-Dioxabicyclo[14.1.0]heptadecane, leucomycin V deriv.
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