CAS 58895-64-0

Nalmefene hydrochloride

Description:

Nalmefene hydrochloride is a synthetic opioid receptor modulator primarily used in the treatment of alcohol dependence. It acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor, which helps to reduce alcohol consumption and cravings. The substance is characterized by its ability to influence the brain's reward pathways, thereby modifying the reinforcing effects of alcohol. Nalmefene hydrochloride is typically administered orally and is known for its relatively favorable safety profile compared to full agonists. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. The hydrochloride salt form enhances its solubility and stability, making it suitable for pharmaceutical formulations. As with any medication, nalmefene hydrochloride may have side effects, including nausea, dizziness, and potential interactions with other substances, necessitating careful monitoring during treatment. Overall, it represents a valuable option in the management of alcohol use disorders, particularly for individuals seeking to reduce their alcohol intake without complete abstinence.

Formula: C₂₁H₂₅NO₃·ClH

InChI: InChI=1/C21H25NO3.ClH/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H/t16-,19+,20+,21-;/m1./s1

InChI key: InChIKey=GYWMRGWFQPSQLK-OPHZJPRHSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=C)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CC6)CC4)[H].Cl

Synonyms:

• (5Alpha)-17-(Cyclopropylmethyl)-6-Methylidene-4,5-Epoxymorphinan-3,14-Diol Hydrochloride
• 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride (1:1), (5α)-
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, (5α)-
• Nalmefene Hcl
• Nih 10365
• Revex
• Nalmefene hydrochloride
• (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol hydrochloride
• Nalmefene Hydrochloride IMP
• (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,hydrochloride
• Unii-K7K69qc05x
• (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, (5alpha)-
• Nalmefene Impurity 2
• (5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol

Nalmefene hydrochloride

CAS: 58895-64-0

Formula: C₂₁H₂₅NO₃·HCl

Purity: (HPLC) ≥ 99.0%

Color and Shape: White powder

Molecular weight: 375.89

Ref: 7W-GP4112

Nalmefene HCl

CAS: 58895-64-0

Formula: C₂₁H₂₅NO₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 339.44 36.46

Ref: 4Z-N-503

Nalmefene hydrochloride

CAS: 58895-64-0

Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS.

Formula: C₂₁H₂₆ClNO₃

Purity: 98% - 99.85%

Color and Shape: Solid

Molecular weight: 375.89

Ref: TM-T6221

Nalmefene hydrochloride

Controlled Product

CAS: 58895-64-0

Opioid receptor antagonist

Formula: C₂₁H₂₅NO₃•HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 375.89 g/mol

Ref: 3D-FN106329

Nalmefene Hydrochloride

Controlled Product

CAS: 58895-64-0

Formula: C₂₁H₂₅NO₃·ClH

Color and Shape: Neat

Molecular weight: 375.889

Ref: TR-N284405