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CAS 58947-95-8

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(±)-Trihexyphenidyl hydrochloride

Description:
(±)-Trihexyphenidyl hydrochloride is a synthetic anticholinergic medication primarily used to treat symptoms of Parkinson's disease and drug-induced extrapyramidal symptoms. It functions by blocking the action of acetylcholine at muscarinic receptors, thereby helping to restore the balance between dopamine and acetylcholine in the central nervous system. This compound appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Its chemical structure features a trihexyphenidyl moiety, characterized by a phenyl ring and a hexyl side chain, contributing to its pharmacological activity. The hydrochloride salt form enhances its stability and solubility. Common side effects may include dry mouth, blurred vision, constipation, and urinary retention, reflecting its anticholinergic properties. Due to its potential for causing cognitive impairment, particularly in elderly patients, careful monitoring is advised during treatment. Overall, (±)-Trihexyphenidyl hydrochloride plays a significant role in managing movement disorders, although its use must be balanced with awareness of its side effects.
Formula:C20H31NO·ClH
InChI:InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChI key:InChIKey=QDWJJTJNXAKQKD-UHFFFAOYSA-N
SMILES:C(CCN1CCCCC1)(O)(C2CCCCC2)C3=CC=CC=C3.Cl
Synonyms:
  • (±)-Trihexyphenidyl hydrochloride
  • 1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
  • 1-Phenyl-1-cyclohexyl-3-piperidyl-1-propanol hydrochloride
  • 1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride
  • 1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)
  • 3-(1-Piperidyl)-1-cyclohexyl-1-phenyl-1-propanol hydrochloride
  • 3-(1-Piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloride
  • Alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol hydrochloride
  • Antitrem
  • Aparkane
  • See more synonyms
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