CAS 58994-96-0

Ranimustine

Description:

Ranimustine, with the CAS number 58994-96-0, is a synthetic alkylating agent primarily used in the treatment of certain types of cancer, particularly brain tumors and lymphomas. It belongs to the class of nitrosoureas, which are known for their ability to cross the blood-brain barrier, making them effective for central nervous system malignancies. Ranimustine functions by introducing alkyl groups into DNA, leading to cross-linking and subsequent disruption of DNA replication and transcription, ultimately inducing cell death. The compound is typically administered intravenously and may exhibit side effects such as myelosuppression, nausea, and potential neurotoxicity. Its pharmacokinetics involve rapid distribution and metabolism, with a relatively short half-life. Ranimustine's efficacy and safety profile make it a valuable option in oncological therapies, although its use requires careful monitoring due to the risk of adverse effects and interactions with other medications. As with all chemotherapeutic agents, the therapeutic regimen should be tailored to the individual patient's condition and response to treatment.

Formula: C₁₀H₁₈ClN₃O₇

InChI: InChI=1/C10H18ClN3O7/c1-20-9-8(17)7(16)6(15)5(21-9)4-12-10(18)14(13-19)3-2-11/h5-9,15-17H,2-4H2,1H3,(H,12,18)

InChI key: InChIKey=AHHFEZNOXOZZQA-ZEBDFXRSSA-N

SMILES: C(NC(N(CCCl)N=O)=O)[C@H]1O[C@H](OC)[C@H](O)[C@@H](O)[C@@H]1O

Synonyms:

• 3-(Methyl-a-D-glucopyranos-6-yl)-1-(2-chloroethyl)-1-nitrosourea
• 58994-96-0
• Cymerin
• Cymerine
• Methyl 6-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-a-D-glucopyranoside
• Methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-α-<span class="text-smallcaps">D</span>-glucopyranoside
• Methyl 6-{[(2-Chloroethyl)(Nitroso)Carbamoyl]Amino}-6-Deoxyhexopyranoside
• Methyl 6-{[(2-chloroethyl)(nitroso)carbamoyl]amino}-6-deoxy-alpha-D-glucopyranoside
• Methyl N-Carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-a-D-glucopyranoside
• NSC 270516
• Ranomustine
• α-<span class="text-smallcaps">D</span>-Glucopyranoside, methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-
• α-D-Glucopyranoside, methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-
• MCNU
• RCL L16,919-6
• Methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-α-D-glucopyranoside
• NSC-0270516
• RANIMUSTINE
• 1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea

Ranimustine

CAS: 58994-96-0

Formula: C₁₀H₁₈ClN₃O₇

Molecular weight: 327.72

Ref: 7W-GP4448

Ranimustine

Controlled Product

CAS: 58994-96-0

Applications A nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera. It can be used in biological study of synthesis of anti-EGFR antibody-drug conjugates. It can also be used in therapeutic use and biological study of BCMA (B-Cell Maturation Antigen) antigen binding proteins.
References Choi, H., et al.: PCT Int. Appl., WO 2017051254 A1 20170330 (2017);

Formula: C₁₀H₁₈ClN₃O₇

Color and Shape: Off White Powder

Molecular weight: 327.72

Ref: TR-R120030

Ranimustine

CAS: 58994-96-0

Anti-cancer; inhibits proliferation of cancer cells by DNA cross-linking

Formula: C₁₀H₁₈ClN₃O₇

Purity: Min. 95%

Molecular weight: 327.72 g/mol

Ref: 3D-FR55382

Ranimustine

CAS: 58994-96-0

Ranimustine (MCNU) can be used for polycythemia vera and chronic myelogenous leukemia research, which is a nitrosourea alkylating agent [1] [3] [4].

Formula: C₁₀H₁₈ClN₃O₇

Color and Shape: Solid

Molecular weight: 327.72

Ref: TM-T60927