CAS 59-14-3

5-Bromo-2′-deoxyuridine

Description:

5-Bromo-2′-deoxyuridine (BrdU) is a synthetic nucleoside analog of thymidine, characterized by the substitution of a bromine atom at the 5-position of the pyrimidine ring. It is commonly used in molecular biology and biochemistry as a marker for DNA synthesis and cell proliferation studies. BrdU is incorporated into newly synthesized DNA in place of thymidine during the S-phase of the cell cycle, allowing researchers to track cell division and proliferation. The compound is typically soluble in water and organic solvents, making it versatile for various experimental conditions. BrdU can be detected using specific antibodies in immunohistochemistry and flow cytometry, facilitating the analysis of cellular processes. Additionally, it has been studied for its potential effects on DNA repair mechanisms and mutagenesis. However, caution is advised when handling BrdU, as it can be cytotoxic at high concentrations. Overall, 5-Bromo-2′-deoxyuridine serves as a valuable tool in research, particularly in studies related to cancer, developmental biology, and neurobiology.

Formula: C₉H₁₁BrN₂O₅

InChI: InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key: InChIKey=WOVKYSAHUYNSMH-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(Br)C(=O)N1

Synonyms:

• (+)-5-Bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 2'-Deoxy-5-Bromorouridine
• 2'-Deoxy-5-Bromouridine
• 5'-Bromodeoxyuridine
• 5-Bdu
• 5-Brdu
• 5-Bromo Deoxyuridine
• 5-Bromo-1-(2-Deoxy-Beta-D-Ribofuranosyl)Uracil
• 5-Bromo-2'-Desoxyuridine
• 5-Bromodesoxyuridine
• 5-Bromouracil deoxyriboside
• 5-Bromouracil-2-deoxyriboside
• 5-bromo-1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione
• BRDU，5-Bromo-2-deoxyuridine
• BUdR
• BrdUrd
• Brdu
• Bromodeoxyuridine
• Broxuridin
• Broxuridina
• Broxuridine
• Brudr
• Nsc 38297
• Uridine, 5-bromo-2'-deoxy-
• (+)-5-BROMO-2'-DEOXYURIDINE
• 5-Bromo-2′-deoxyuridine

5-Bromo-2'-deoxyuridine

CAS: 59-14-3

Formula: C₉H₁₁BrN₂O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 307.10

Ref: 3B-B1575

5-Bromo-2'-deoxyuridine, 99%

CAS: 59-14-3

5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to targ

Formula: C₉H₁₁BrN₂O₅

Purity: 99%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 307.10

Ref: 02-H27260

5-Bromo-2'-deoxyuridine

CAS: 59-14-3

Formula: C₉H₁₁BrN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.0980

Ref: IN-DA0034KJ

5-Bromo-2'-deoxyuridine

CAS: 59-14-3

5-Bromo-2'-deoxyuridine

Formula: C₉H₁₁BrN₂O₅

Purity: By hplc: 99.9% by area (Typical Value in Batch COA)

Color and Shape: white to off white powder

Molecular weight: 307.10g/mol

Ref: 54-BI2048

5-BrdU

CAS: 59-14-3

5-BrdU

Purity: ≥98%

Molecular weight: 307.1g/mol

Ref: 54-BUP17104

5-Bromo-2''-deoxyuridine

CAS: 59-14-3

Formula: C₉H₁₁BrN₂O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 307.10

Ref: 7W-GE3595

5-BrdU

CAS: 59-14-3

5-BrdU (Broxuridine) is a nucleoside analogue, detect proliferating cells and compete with thymidine for incorporation into DNA. High-Quality, Low-Cost!

Formula: C₉H₁₁BrN₂O₅

Purity: 99.54% - 99.87%

Color and Shape: Crystals From Absolute Ethanol Physical Description White Crystalline Powder (Ntp 1992)

Molecular weight: 307.1

Ref: TM-T6794

5-Bromo-2'-deoxyuridine

Controlled Product

CAS: 59-14-3

Applications 5-Bromo-2'-deoxyuridine is a thymidine analogue used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase.
References Boccadoro, M., et al.: Tumor, 72, 135 (1986), Fivan, A. L.: Flow Cytometry, First Principles, New York, (1992),

Formula: C₉H₁₁BrN₂O₅

Color and Shape: White

Molecular weight: 307.10

Ref: TR-B683250

5-Bromo-2'-deoxyuridine

CAS: 59-14-3

5-Bromo-2'-deoxyuridine (5-BrDU) is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. It is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-BrDU has been shown to induce preconditioning in vivo, reducing neuronal injury after ischemia. This drug also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases such as Alzheimer's disease. 5-BrDU has been shown to inhibit the polymerase chain reaction in wild-type strains of bacteria, but not in strains with a mutation in their DNA gyrase genes.

Formula: C₉H₁₁BrN₂O₅

Purity: Min. 99 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 307.1 g/mol

Ref: 3D-NB06315

5-Bromo-2′-deoxyuridine

CAS: 59-14-3

Formula: C₉H₁₁BrN₂O₅

Purity: 95%

Color and Shape: Solid, White powder

Molecular weight: 307.1

Ref: 10-F092742

5-Bromo-2-Deoxyuridine extrapure, 98%

CAS: 59-14-3

Formula: C₉H₁₁N₂O₅Br

Purity: min. 98%

Color and Shape: White, Crystalline powder

Molecular weight: 307.10

Ref: SR-57418

5-Bromo-2-Deoxyuridine ExiPlus, Multi-Compendial, 98%

CAS: 59-14-3

Formula: C₉H₁₁N₂O₅Br

Purity: min. 98%

Color and Shape: White, Crystalline powder

Molecular weight: 307.10

Ref: SR-11849