CAS 59-26-7

Tocainide

Description:

Tocainide is a pharmaceutical compound primarily used as an antiarrhythmic agent, particularly in the treatment of ventricular arrhythmias. It belongs to the class of drugs known as sodium channel blockers, which work by inhibiting the influx of sodium ions during the depolarization phase of the cardiac action potential, thereby stabilizing the cardiac membrane and reducing abnormal electrical activity. Tocainide is characterized by its chemical formula, which includes a piperidine ring, and it is typically administered orally. The substance has a moderate solubility in water and is known for its relatively low toxicity compared to other antiarrhythmic agents. Tocainide's pharmacokinetics involve hepatic metabolism, and it is excreted primarily through the kidneys. While effective, its use may be limited by side effects such as gastrointestinal disturbances and potential for blood dyscrasias. Due to these factors, monitoring is essential during treatment. Overall, Tocainide represents an important option in the management of certain cardiac arrhythmias, although its clinical use has diminished with the advent of newer agents.

Formula: C₁₀H₁₄N₂O

InChI: InChI=1/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

InChI key: InChIKey=NCYVXEGFNDZQCU-UHFFFAOYSA-N

SMILES: C(N(CC)CC)(=O)C=1C=CC=NC1

Synonyms:

• Anacardone
• Astrocar
• Inicardio
• Kardiamid
• Leptamin
• Mediamid
• Niamine
• Nicamide
• Nicetamide
• Nicethamid
• Nicor
• Nicotinic Acid Diethyl Amide
• Nikethamide
• Nikotin
• N,N-diethyl-3-pyridinecarboxamide
• N,N-Diethylnicotinamide
• Percoral
• Procardine
• Pyridine-3-Carboxyldiethylamide
• Pyridine-3-Carboxylic Acid Diethylamide
• Reformin
• Salvacord
• Stellamine
• Stimulin
• Vasozol
• Diethyl-Nicotamide
• Dietilamide-Carbopiridina
• Dinacoryl
• Betapyrimidum
• Camphozone
• Cardiamid
• Cardiamine
• Cardamine
• Citocor
• Coracon
• Coraethamidum
• Coramine
• Corazone
• Cordiamin
• Cordynil
• Corediol
• Coretone
• Cormid
• Cornotone
• Corvitan
• Corvotone
• Danamine
• Elitone
• Hansacor
• N,N-diethylpyridine-3-carboxamide
• 3-(N,N-Diethylcarbamoyl)pyridine
• 3-Pyridinecarboxamide, N,N-diethyl-
• Anacordone
• Canfodiamina
• Carbamidal
• Cardiamide
• Cardimon
• Coractiv N
• Coramine (pharmaceutical)
• Cordiamine
• Cormed
• Cormotyl
• Corvin
• Corvitol
• Diethylnicotinamide
• Dynacoryl
• Ecoran
• Eucoran
• Kordiamin
• Nicetamida
• Nicethamide
• Ni-Cor
• Nicorine
• Nicotinamide, N,N-diethyl-
• Nicotinic acid diethylamide
• Nikardin
• Niketamide
• Niketamine
• Nikethamid
• Niketharol
• Nikethyl
• Nikorin
• Niquetamide
• Nsc 130820
• Nsc 169863
• Nsc 62103
• Pyricardyl
• Pyridine-3-carboxydiethylamide
• Rehormin
• Salvacard
• Sancora
• Solyacord
• Ventramine
• Nickethamide
• NIKETHAMIDUM
• LABOTEST-BB LT00134638

N,N-Diethylnicotinamide

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Purity: >98.0%(GC)(T)

Color and Shape: White or Colorless to Light orange to Yellow powder to lump to clear liquid

Molecular weight: 178.24

Ref: 3B-D0514

NIKETHAMIDE CRS

CAS: 59-26-7

NIKETHAMIDE CRS

Formula: C₁₀H₁₄N₂O

Color and Shape: May Be Present In Various Forms. Oily Liquid. Crystalline Mass. Yellow. Transparent.

Molecular weight: 178.231

Ref: 41-N0800000

Nikethamide

CAS: 59-26-7

Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of end

Formula: C₁₀H₁₄N₂O

Purity: 99.42%

Color and Shape: Followed By A Faint Sensation Of The Warmth (Ntp 1992)

Molecular weight: 178.23

Ref: TM-T0048

Nikethamide

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Purity: ≥ 98.0%

Color and Shape: Colourless or pale yellow oily liquid, or crystalline mass

Molecular weight: 178.23

Ref: 7W-GP1304

Nikethamide, EP grade

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Purity: 99.0 - 101.0 % (anhydrous substance)

Color and Shape: An oily liquid or a crystalline mass, colourless or pale yellow

Molecular weight: 178.23

Ref: 7W-GP1011

Nikethamide

CAS: 59-26-7

Color and Shape: Off-White

Ref: 04-C15525900

Nikethamide

CAS: 59-26-7

Color and Shape: Neat

Ref: 61-FOR0627.00

Nikethamide

Controlled Product

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Color and Shape: Neat

Molecular weight: 178.23

Ref: 86-MM0627.00

N,N-Diethylnicotinamide

CAS: 59-26-7

N,N-Diethylnicotinamide

Purity: 97%

Molecular weight: 178.23g/mol

Ref: 54-OR926552

N,N-Diethylnicotinamide (Nikethamide)

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Molecular weight: 178.24

Ref: 4Z-N-133029

N,N-Diethylnicotinamide (Nikethamide)

CAS: 59-26-7

Applications Nikethamide is an analeptic agent. It was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now considered to be of no value for such purposes, and may in fact be dangerous.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bean, J., et al.: Biochem. Pharm., 35, 1011 (1986); Chakaravarti, M.: J. Pharmacol., 67, 153 (1939); Naik, S., et al.: Biochem. Pharm., 18, 2038 (1969); Martindale, The Extra Pharmacopoeia, 30th ed,, 1229

Formula: C₁₀H₁₄N₂O

Color and Shape: Off-White

Molecular weight: 178.23

Ref: TR-N460000

N,N-Diethylnicotinamide

Controlled Product

CAS: 59-26-7

N,N-Diethylnicotinamide is a nicotinamide derivative that is used as an anti-inflammatory agent. It has been shown to inhibit the activity of enzymes such as acetylcholinesterase, phospholipase A2, and cyclooxygenase. N,N-Diethylnicotinamide has a synergistic effect with pentobarbital sodium in inducing chronic pulmonary inflammation in rats. This drug also has an acid complexing effect on fatty acids and nitrogen atoms. The coordination geometry of this drug is octahedral with two nitrogen atoms coordinated to one metal ion. N,N-Diethylnicotinamide can be synthesized by reacting nicotinic acid with diethylamine in the presence of 1 equivalent of hydrogen gas.

Formula: C₁₀H₁₄N₂O

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 178.23 g/mol

Ref: 3D-FD31942

N,N-Diethylnicotinamide

CAS: 59-26-7

Formula: C₁₀H₁₄N₂O

Molecular weight: 178.24

Ref: ST-EA-CP-N35013