CAS 59-26-7
:Tocainide
Description:
Tocainide is a pharmaceutical compound primarily used as an antiarrhythmic agent, particularly in the treatment of ventricular arrhythmias. It belongs to the class of drugs known as sodium channel blockers, which work by inhibiting the influx of sodium ions during the depolarization phase of the cardiac action potential, thereby stabilizing the cardiac membrane and reducing abnormal electrical activity. Tocainide is characterized by its chemical formula, which includes a piperidine ring, and it is typically administered orally. The substance has a moderate solubility in water and is known for its relatively low toxicity compared to other antiarrhythmic agents. Tocainide's pharmacokinetics involve hepatic metabolism, and it is excreted primarily through the kidneys. While effective, its use may be limited by side effects such as gastrointestinal disturbances and potential for blood dyscrasias. Due to these factors, monitoring is essential during treatment. Overall, Tocainide represents an important option in the management of certain cardiac arrhythmias, although its clinical use has diminished with the advent of newer agents.
Formula:C10H14N2O
InChI:InChI=1/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChI key:InChIKey=NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES:C(N(CC)CC)(=O)C=1C=CC=NC1
Synonyms:- Anacardone
- Astrocar
- Inicardio
- Kardiamid
- Leptamin
- Mediamid
- Niamine
- Nicamide
- Nicetamide
- Nicethamid
- Nicor
- Nicotinic Acid Diethyl Amide
- Nikethamide
- Nikotin
- N,N-diethyl-3-pyridinecarboxamide
- N,N-Diethylnicotinamide
- Percoral
- Procardine
- Pyridine-3-Carboxyldiethylamide
- Pyridine-3-Carboxylic Acid Diethylamide
- Reformin
- Salvacord
- Stellamine
- Stimulin
- Vasozol
- Diethyl-Nicotamide
- Dietilamide-Carbopiridina
- Dinacoryl
- Betapyrimidum
- Camphozone
- Cardiamid
- Cardiamine
- Cardamine
- Citocor
- Coracon
- Coraethamidum
- Coramine
- Corazone
- Cordiamin
- Cordynil
- Corediol
- Coretone
- Cormid
- Cornotone
- Corvitan
- Corvotone
- Danamine
- Elitone
- Hansacor
- N,N-diethylpyridine-3-carboxamide
- 3-(N,N-Diethylcarbamoyl)pyridine
- 3-Pyridinecarboxamide, N,N-diethyl-
- Anacordone
- Canfodiamina
- Carbamidal
- Cardiamide
- Cardimon
- Coractiv N
- Coramine (pharmaceutical)
- Cordiamine
- Cormed
- Cormotyl
- Corvin
- Corvitol
- Diethylnicotinamide
- Dynacoryl
- Ecoran
- Eucoran
- Kordiamin
- Nicetamida
- Nicethamide
- Ni-Cor
- Nicorine
- Nicotinamide, N,N-diethyl-
- Nicotinic acid diethylamide
- Nikardin
- Niketamide
- Niketamine
- Nikethamid
- Niketharol
- Nikethyl
- Nikorin
- Niquetamide
- Nsc 130820
- Nsc 169863
- Nsc 62103
- Pyricardyl
- Pyridine-3-carboxydiethylamide
- Rehormin
- Salvacard
- Sancora
- Solyacord
- Ventramine
- Nickethamide
- NIKETHAMIDUM
- LABOTEST-BB LT00134638
- See more synonyms
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N,N-Diethylnicotinamide
CAS:Formula:C10H14N2OPurity:>98.0%(GC)(T)Color and Shape:White or Colorless to Light orange to Yellow powder to lump to clear liquidMolecular weight:178.24N,N-Diethylnicotinamide
CAS:N,N-DiethylnicotinamideFormula:C10H14N2OPurity:97%Molecular weight:178.23095Nikethamide
CAS:Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of endFormula:C10H14N2OPurity:99.42%Color and Shape:SolidMolecular weight:178.23Nikethamide
CAS:Formula:C10H14N2OPurity:≥ 98.0%Color and Shape:Colourless or pale yellow oily liquid, or crystalline massMolecular weight:178.23Nikethamide, EP grade
CAS:Formula:C10H14N2OPurity:99.0 - 101.0 % (anhydrous substance)Color and Shape:An oily liquid or a crystalline mass, colourless or pale yellowMolecular weight:178.23N,N-Diethylnicotinamide (Nikethamide)
CAS:Applications Nikethamide is an analeptic agent. It was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now considered to be of no value for such purposes, and may in fact be dangerous.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bean, J., et al.: Biochem. Pharm., 35, 1011 (1986); Chakaravarti, M.: J. Pharmacol., 67, 153 (1939); Naik, S., et al.: Biochem. Pharm., 18, 2038 (1969); Martindale, The Extra Pharmacopoeia, 30th ed,, 1229Formula:C10H14N2OColor and Shape:NeatMolecular weight:178.23
