CAS 59-42-7

(-)-Phenylephrine

Description:

(-)-Phenylephrine is a synthetic compound primarily used as a decongestant and a vasopressor in medical applications. It is an aromatic amine with a phenethylamine structure, characterized by a hydroxyl group on the benzene ring and a primary amine group. This compound exists as a chiral molecule, with the (-)-enantiomer being the biologically active form. It is typically presented as a white to off-white crystalline powder, soluble in water and alcohol, but insoluble in non-polar solvents. The mechanism of action involves selective stimulation of alpha-1 adrenergic receptors, leading to vasoconstriction and increased blood pressure, making it useful in treating hypotension and nasal congestion. Additionally, (-)-Phenylephrine is often included in over-the-counter medications for cold and allergy relief. Its safety profile is generally favorable, though it may cause side effects such as hypertension and reflex bradycardia. As with any medication, it is important to use it under appropriate medical guidance to avoid potential adverse effects.

Formula: C₉H₁₃NO₂

InChI: InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1

InChI key: InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N

SMILES: [C@@H](CNC)(O)C1=CC(O)=CC=C1

Synonyms:

• (-)-Phenylephrine
• (-)-m-Hydroxy-α-(methylaminomethyl)benzyl alcohol
• (-)-m-Oxedrine
• (-)-m-Synephrine
• (R)-(-)-Phenylephrine
• (R)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol
• (αR)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol
• 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol
• <span class="text-smallcaps">L</span>-Phenylephedrine
• Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (R)-
• Benzyl alcohol, m-hydroxy-α-[(methylamino)methyl]-
• Fenilefrina
• Iriphrin
• L-Phenylephedrine
• Mesaton
• Mesatone
• Metaoxedrin
• Metaoxedrine
• Metasympatol
• Metasynephrine
• Mezaton
• Neo-Synephrine
• Phenylephrin
• R(-)-Mezaton
• Visadron
• l-Phenylephrine
• l-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol
• m-Methylaminoethanolphenol
• m-Sympathol
• m-Sympatol
• Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-
• (2R)-2-hydroxy-2-(3-hydroxyphenyl)-N-methylethanaminium chloride

Phenylephrine

CAS: 59-42-7

Color and Shape: Neat

Ref: 61-FOR0287.00

PHENYLEPHRINE CRS

CAS: 59-42-7

PHENYLEPHRINE CRS

Ref: 41-P1240000

(αR)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol

CAS: 59-42-7

Formula: C₉H₁₃NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 167.2050

Ref: IN-DA003TPN

L-Phenylephrine, EP grade

CAS: 59-42-7

Formula: C₉H₁₃NO₂

Purity: ≤ 0.1%

Color and Shape: White or almost white crystalline powder

Molecular weight: 167.21

Ref: 7W-GP2892

L-Phenylephrine

CAS: 59-42-7

Formula: C₉H₁₃NO₂

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White or off-white crystalline powder

Molecular weight: 167.21

Ref: 7W-GP5595

L-Phenylephrine

CAS: 59-42-7

Formula: C₉H₁₃NO₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 167.21

Ref: 3B-P0395

Phenylephrine

Controlled Product

CAS: 59-42-7

Formula: C₉H₁₃NO₂

Color and Shape: Neat

Molecular weight: 167.20

Ref: 86-MM0287.00

Phenylephrine

CAS: 59-42-7

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Formula: C₉H₁₃NO₂

Purity: 99.5% - 99.89%

Color and Shape: Solid

Molecular weight: 167.21

Ref: TM-T17310

L-Phenylephrine

Controlled Product

CAS: 59-42-7

Applications L-Phenylephrine (cas# 59-42-7) is a useful research chemical.

Formula: C₉H₁₃NO₂

Color and Shape: Neat

Molecular weight: 167.20

Ref: TR-P320688

Phenylephrine

CAS: 59-42-7

Phenylephrine is a sympathomimetic drug that stimulates α-adrenergic receptors. It is used to relieve the symptoms of chronic cough and to reduce blood pressure in patients with high blood pressure. Phenylephrine has been shown to inhibit the activity of toll-like receptor 4 on human cells, leading to a reduction in proinflammatory cytokines. In addition, phenylephrine has been shown to inhibit the activity of TLR2 on human cells, which leads to an increase in intracellular calcium levels. The effects of phenylephrine are mediated by activation of non-selective cation channels and inhibition of phosphodiesterases. This drug is also used as a mydriatic and cycloplegic agent for eye disorders such as glaucoma or ocular hypertension.

Formula: C₉H₁₃NO₂

Purity: Min. 95%

Molecular weight: 167.21 g/mol

Ref: 3D-AAA05942