CAS 59-48-3

Oxindole

Description:

Oxindole is an organic compound characterized by its bicyclic structure, which consists of an indole ring fused to a carbonyl group. It is a white to off-white crystalline solid that is soluble in organic solvents such as ethanol and chloroform but has limited solubility in water. The molecular formula of oxindole is C8H7NO, and it features a nitrogen atom within the indole framework, contributing to its basic properties. Oxindole is known for its role in various biological activities, including potential applications in pharmaceuticals, where it serves as a scaffold for the development of drugs targeting neurological disorders and other conditions. Additionally, it can participate in various chemical reactions, such as electrophilic substitutions and cyclizations, making it a valuable intermediate in organic synthesis. Its derivatives have been studied for their anti-inflammatory, analgesic, and antitumor properties, highlighting the compound's significance in medicinal chemistry. Overall, oxindole is a versatile compound with important implications in both research and industry.

Formula: C₈H₇NO

InChI: InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)

InChI key: InChIKey=JYGFTBXVXVMTGB-UHFFFAOYSA-N

SMILES: O=C1CC=2C(N1)=CC=CC2

Synonyms:

• 1,3-Dihydroindol-2-one
• 1,3-dihydro-2H-indol-2-one
• 2,3-Dihidroindol-2-Ona
• 2,3-Dihydro-1H-indol-2-one
• 2,3-Dihydroindol-2-One
• 2,3-Dihydroindol-2-on
• 2,3-Dihydroindole-2-One
• 2-Indolinone
• 2-Indolone
• 2-Oxindole
• 2-Oxo-2,3-dihydroindole
• 2-Oxoindole
• 2-Oxoindoline
• 2H-Indol-2-one, 1,3-dihydro-
• Indol-2(3H)-one
• Indolin-2-one
• Indoline-2-one
• Nsc 274863
• O-(Aminophenyl)Acetic acid Lactam
• Oxidinole (Indolin-2-One)
• Oxindol
• Timtec-Bb Sbb004215

Oxindole

CAS: 59-48-3

Formula: C₈H₇NO

Purity: >98.0%(GC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 133.15

Ref: 3B-O0272

Oxindole, 97+%

CAS: 59-48-3

Oxindole is considered as indole analogue, which shows pharmacological activity. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code

Formula: C₈H₇NO

Purity: 97+%

Color and Shape: White to dark cream to cream to brown, Powder

Molecular weight: 133.15

Ref: 02-A18764

1,3-Dihydro-2H-indol-2-one

CAS: 59-48-3

Color and Shape: Neat

Ref: 61-FOR0006.02

Oxindole

CAS: 59-48-3

Lactams, nesoi

Formula: C₈H₇NO

Color and Shape: White Crystalline Powder

Molecular weight: 133.05276

Ref: 45-1A09990

Indolin-2-One

CAS: 59-48-3

Formula: C₈H₇NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 133.1473

Ref: IN-DA003R0B

Oxindole

CAS: 59-48-3

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block.

Formula: C₈H₇NO

Purity: 97.42% - 99.65%

Color and Shape: Off-White Crystalline Powder

Molecular weight: 133.15

Ref: TM-Fr16741

2-Oxindole

CAS: 59-48-3

2-Oxindole

Formula: C₈H₇NO

Purity: 98%

Color and Shape: light orange powder

Molecular weight: 133.15g/mol

Ref: 54-OR30278

Oxindole

CAS: 59-48-3

Oxindole

Purity: ≥95%

Molecular weight: 133.15g/mol

Ref: 54-BUP19393

Diclofenac EP Impurity E (Oxindole)

CAS: 59-48-3

Formula: C₈H₇NO

Color and Shape: Brown Solid

Molecular weight: 133.15

Ref: 4Z-D-069

1,3-Dihydro-2H-indol-2-one

CAS: 59-48-3

Formula: C₈H₇NO

Color and Shape: Neat

Molecular weight: 133.15

Ref: 86-MM0006.02

Oxindole

CAS: 59-48-3

Formula: C₈H₇NO

Purity: (HPLC) ≥ 97.0%

Color and Shape: White to light yellow or light orange crystalline powder

Molecular weight: 133.15

Ref: 7W-GK4423

Oxindole (2-Indolone)

Controlled Product

CAS: 59-48-3

Applications Indole analogue; shows pharmacological activity.
References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),

Formula: C₈H₇NO

Color and Shape: Light Red

Molecular weight: 133.15

Ref: TR-I627300

Diclofenac EP Impurity E

CAS: 59-48-3

Formula: C₈H₇NO

Molecular weight: 133.15

Ref: ST-EA-CP-D20005

2-Indolone

CAS: 59-48-3

2-Indolone is a synthetic compound that belongs to the class of heterocyclic compounds. It is a trifluoroacetic acid derivative that has been shown to have potent antitumor activity, and it also inhibits cell proliferation. 2-Indolone has been shown to be an effective treatment for inflammatory diseases such as rheumatoid arthritis and Crohn's disease. This compound has been shown to bind to response elements in the promoter region of genes in the basic fibroblast line, and this binding leads to increased expression of gene products involved in inflammation and tumor suppression. The reaction mechanism for 2-indolone involves a two-step process, with activation energies for both steps being high. The first step involves protonation of the C2 hydroxyl group by trifluoroacetic acid, which leads to its displacement by hydrogen from water molecule H2O. In the second step, the oxindole ring opens up, with displacement of

Formula: C₈H₇NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 133.15 g/mol

Ref: 3D-FI24580

1,3-Dihydro-2H-indol-2-one

CAS: 59-48-3

Formula: C₈H₇NO

Purity: 97%

Color and Shape: Solid, Chunks or Crystalline Powder

Molecular weight: 133.15

Ref: 10-F093498

Oxindole

CAS: 59-48-3

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

Formula: C₈H₇NO

Purity: 99.34%

Color and Shape: Off-White Crystalline Powder

Molecular weight: 133.15

Ref: TM-FR16741