CAS 59-96-1

(±)-Phenoxybenzamine

Description:

(±)-Phenoxybenzamine is a chemical compound classified as an irreversible alpha-adrenergic antagonist. It is primarily used in the treatment of conditions such as pheochromocytoma, a type of tumor that secretes catecholamines, leading to hypertension. The compound is characterized by its ability to form covalent bonds with alpha-adrenergic receptors, resulting in prolonged receptor blockade. This action can lead to a decrease in blood pressure and other sympathetic nervous system effects. (±)-Phenoxybenzamine is typically administered in its hydrochloride salt form and is known for its lipophilicity, which allows it to cross biological membranes effectively. The compound has a relatively low solubility in water but is soluble in organic solvents. Its chemical structure features a phenoxy group attached to a benzylamine moiety, contributing to its pharmacological properties. Due to its irreversible binding nature, the effects of (±)-Phenoxybenzamine can last longer than typical competitive antagonists, necessitating careful monitoring of patients during treatment.

Formula: C₁₈H₂₂ClNO

InChI: InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3

InChI key: InChIKey=QZVCTJOXCFMACW-UHFFFAOYSA-N

SMILES: C(N(C(COC1=CC=CC=C1)C)CCCl)C2=CC=CC=C2

Synonyms:

• (.+-.)-Phenoxybenzamine
• 688A
• Bensylyt
• Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
• Benzylyt
• Dibenylin
• Dibenyline
• Dibenzyline
• Fenoxibenzamina
• N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine
• N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
• N-Phenoxyisopropyl-N-benzyl-β-chloroethylamine
• Phenoxybenzamin

Phenoxybenzamine

CAS: 59-96-1

Phenoxybenzamine blocks α-1 receptors, potentially reducing neuroinflammation post brain trauma.

Formula: C₁₈H₂₂ClNO

Purity: 98%

Color and Shape: Crystals From Petroleum Ether Solid

Molecular weight: 303.83

Ref: TM-T1158L