CAS 59088-21-0
:uracyl dna glycosylase F. E. coli
Description:
Uracil-DNA glycosylase (UDG) from *Escherichia coli* is an enzyme that plays a crucial role in DNA repair by recognizing and removing uracil residues from DNA. This enzyme is essential for maintaining the integrity of the genetic material, as uracil can arise from the deamination of cytosine or be incorporated into DNA during replication. The removal of uracil prevents mutations and ensures proper DNA function. UDG operates through a mechanism that involves the hydrolysis of the N-glycosidic bond between uracil and the deoxyribose sugar, resulting in the formation of an abasic site that can be further processed by other repair enzymes. The enzyme is characterized by its specificity for uracil over other nucleobases and is typically found in the nucleus of cells. Its activity is vital for cellular health, and its dysfunction can lead to increased mutation rates and genomic instability. The CAS number 59088-21-0 uniquely identifies this enzyme in chemical databases, facilitating research and application in molecular biology and genetics.
- Glycosidase, deoxyribonucleate uracil
- Endonuclease, N-glycosylase III
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