Description:4-Thiouracil is a sulfur-containing derivative of uracil, classified as a pyrimidine base. Its chemical formula is C4H4N2O2S, and it features a thiol group (-SH) at the 4-position of the uracil ring, which distinguishes it from uracil itself. This compound is typically a white to off-white crystalline solid and is soluble in water and alcohol. 4-Thiouracil is known for its role as an antithyroid agent, as it inhibits the synthesis of thyroid hormones by blocking the incorporation of iodine into tyrosine residues in thyroglobulin. Additionally, it has applications in biochemistry and molecular biology, particularly in studies involving RNA and nucleic acid metabolism. The compound's mechanism of action and its ability to interfere with nucleic acid synthesis make it a valuable tool in research and therapeutic contexts. However, like many chemical substances, it should be handled with care due to potential toxicity and side effects associated with its use.
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