CAS 59110-35-9

Pamatolol

Description:

Pamatolol, with the CAS number 59110-35-9, is a beta-adrenergic antagonist, commonly known as a beta-blocker. It is primarily used in the management of cardiovascular conditions, particularly hypertension and certain types of arrhythmias. As a non-selective beta-blocker, Pamatolol works by blocking the action of catecholamines, such as adrenaline, on beta-adrenergic receptors, leading to a decrease in heart rate and myocardial contractility. This results in reduced cardiac output and lower blood pressure. The compound is characterized by its ability to improve exercise tolerance in patients with angina and to provide protective effects against heart failure. Pamatolol may also exhibit additional properties, such as antiarrhythmic effects. However, like other beta-blockers, it may have side effects, including fatigue, dizziness, and potential respiratory issues in susceptible individuals. It is important for patients to consult healthcare professionals for appropriate dosing and monitoring while using this medication.

Formula: C₁₆H₂₆N₂O₄

InChI: InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)

InChI key: InChIKey=UGENBJKPPGFFAT-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(CCNC(OC)=O)C=C1

Synonyms:

• (2-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl) ethyl)carbamic acid methyl ester
• Carbamic acid, N-[2-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethyl]-, methyl ester
• Carbamic acid, [2-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethyl]-, methyl ester
• Methyl ( -)-4-(2-hydroxy-3-(isopropylamino)propoxy)phenethylcarbamat
• Methyl (2-{4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl}Ethyl)Carbamate
• Methyl N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamat
• Pamatolol [INN]
• Pamatololum
• Pamatololum [INN-Latin]
• Unii-20G2S6V53L
• Pamatolol

Pamatolol

CAS: 59110-35-9

Pamatolol is a beta-blocker that is used in the treatment of high blood pressure and heart disease. It has been shown to inhibit the production of fatty acids in rat liver microsomes, which may play an important role in cancer. Pamatolol has also been shown to have anti-inflammatory effects and to inhibit the production of cytokines, such as IL-1β, IL-6, and TNF-α. The drug also inhibits the activity of 2-adrenergic receptors, which are involved in inflammatory bowel disease. This medication does not affect the activity of prostaglandin H synthase (prostaglandin C synthase), which plays an important role in inflammatory bowel disease.
Pamatolol has been shown to be effective against human liver cells, but long-term studies on its toxicity are still required.

Formula: C₁₆H₂₆N₂O₄

Purity: Min. 95%

Molecular weight: 310.39 g/mol

Ref: 3D-JCA11035

Pamatolol

CAS: 59110-35-9

Pamatolol is a selective and potent beta-adrenoceptor antagonist that has not shown sympathomimetic activity in ex vivo experiments.

Formula: C₁₆H₂₆N₂O₄

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 310.39

Ref: TM-T16431