CAS 59247-13-1

(ganglioside gt1B) from bovine brain

Description:

Ganglioside GT1b is a complex glycosphingolipid predominantly found in the nervous tissue, particularly in the brain of mammals, including bovines. It is characterized by its structure, which consists of a ceramide backbone linked to a carbohydrate moiety that includes sialic acid residues. This ganglioside plays a crucial role in cell signaling, neuronal development, and the modulation of synaptic transmission. GT1b is known for its involvement in various biological processes, including neuroprotection and cell recognition. Its presence in the brain contributes to the formation of lipid rafts, which are essential for the proper functioning of membrane proteins. Additionally, gangliosides like GT1b are implicated in neurodegenerative diseases and are studied for their potential therapeutic applications. The CAS number 59247-13-1 specifically identifies this compound, facilitating its recognition in scientific literature and databases. Overall, ganglioside GT1b is significant in neuroscience and biochemistry due to its structural complexity and functional importance in cellular interactions within the nervous system.

Formula: C₈₈H₁₅₇N₅O₄₄

InChI: InChI=1/C88H157N5O44/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-56(107)92-37-51(45(101)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)124-80-66(113)65(112)70(54(42-98)127-80)129-82-69(116)77(136-87(84(120)121)35-46(102)57(89)72(132-87)61(108)49(105)38-94)71(55(43-99)128-82)130-79-60(93-44(3)100)75(63(110)52(40-96)125-79)131-81-68(115)76(64(111)53(41-97)126-81)135-86(83(118)119)34-47(103)59(91)74(134-86)67(114)78(117)137-88(85(122)123)36-48(104)58(90)73(133-88)62(109)50(106)39-95/h30,32,45-55,57-82,94-99,101-106,108-117H,4-29,31,33-43,89-91H2,1-3H3,(H,92,107)(H,93,100)(H,118,119)(H,120,121)(H,122,123)/b32-30+/t45?,46-,47-,48-,49?,50?,51?,52-,53-,54+,55-,57+,58+,59+,60-,61?,62?,63+,64+,65+,66+,67?,68-,69-,70+,71+,72+,73+,74+,75-,76+,77-,78?,79+,80+,81+,82+,86+,87+,88+/m0/s1

Synonyms:

• Ganglioside, GT1
• GT(1)Ganglioside
• GT1b Ganglioside
• Ganglioside GT1b
• N-Acetylneuraminylgalactosyl-N-acetylgalactosaminyl -(N-acetylneuraminyl-N-acetylneuraminyl)galactosyl- glucosylceramide
• Polysialoganglioside
• Trisialoganglioside GT1b
• (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-4-[(2S,3S,4R,5R,6S)-4-[(2R,4S,5R,6R)-5-amino-6-[2-[(2R,4S,5R,6R)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-ethyl]-2-carboxy-4-hydroxy-tetrahydropyran-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-carboxylic acid

Ganglioside GT1b Mixture (sodium salt)

CAS: 59247-13-1

GT1b, a trisialoganglioside, binds neurotoxins and MCPyV VP1, inhibits IL-6, IL-10, IgG, IgM, IgA, and has C18:1/C20:1 sphingoid backbones.

Formula: C₉₅H₁₆₂N₅O₄₇₃Na

Color and Shape: Solid

Molecular weight: 2195.27

Ref: TM-T36862

Trisialoganglioside GT1b NH4+ salt

CAS: 59247-13-1

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1105

GT1b-Ganglioside

CAS: 59247-13-1

Formula: C₉₅H₁₆₂N₅O₄₇·3Na

Purity: ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 2159.3

Ref: 7W-GC4593

GT1b-Ganglioside sodium

CAS: 59247-13-1

GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Formula: C₉₅H₁₆₅N₅O₄₈·xNa

Color and Shape: White Powder

Molecular weight: 2,145.33 g/mol

Ref: 3D-OG03923

GT1b-Ganglioside ammonium

CAS: 59247-13-1

GT1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Formula: C₉₅H₁₆₅N₅O₄₈·xNH₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 2,145.33 g/mol

Ref: 3D-OG167138

Ganglioside GT1b trisodium salt

Controlled Product

CAS: 59247-13-1

Applications Ganglioside GT1b trisodium salt (bovine brain) is a glycosphingolipid neuroprotectant.

Formula: C₉₅H₁₆₂N₅Na₃O₄₇

Color and Shape: Neat

Molecular weight: 2195.28

Ref: TR-G235078

Ganglioside GT1b

CAS: 59247-13-1

Formula: C₈₈H₁₅₇N₅O₄₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 1989.1952799999976

Ref: IN-DA01CBD9