CAS 59338-93-1

Alizapride

Description:

Alizapride is a chemical compound classified as an atypical antipsychotic and is primarily used for its antiemetic properties. It belongs to the class of substituted benzamides and is known for its ability to antagonize dopamine receptors, particularly D2 receptors, which contributes to its therapeutic effects. Alizapride exhibits a moderate affinity for serotonin receptors as well, which may play a role in its efficacy in treating nausea and vomiting. The compound is typically administered orally and has been utilized in various clinical settings, particularly in managing chemotherapy-induced nausea. Its pharmacological profile includes a relatively low incidence of extrapyramidal side effects compared to other antipsychotics, making it a preferred choice in certain patient populations. Alizapride is also characterized by its solubility in organic solvents and limited solubility in water, which influences its formulation and delivery methods. Overall, Alizapride's unique receptor activity and side effect profile make it a noteworthy agent in the realm of antiemetic therapies.

Formula: C₁₆H₂₁N₅O₂

InChI: InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)

InChI key: InChIKey=KSEYRUGYKHXGFW-UHFFFAOYSA-N

SMILES: O(C)C=1C=C2C(=CC1C(NCC3N(CC=C)CCC3)=O)N=NN2

Synonyms:

• 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-
• 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]-
• 6-Methoxy-N-[(1-Prop-2-Enylpyrrolidin-2-Yl)Methyl]-2H-Benzotriazole-5-Carboxamide Hydrochloride
• 6-Methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
• 6-methoxy-N-[(1-prop-2-en-1-ylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide hydrochloride
• 6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-benzotriazole-5-carboxamide
• Alizaprid
• Alizaprida
• Alizapride Hydrochloride
• Alizapride

Alizapride

CAS: 59338-93-1

Formula: C₁₆H₂₁N₅O₂

Molecular weight: 315.37

Ref: 7W-GP4425

Alizapride

CAS: 59338-93-1

Alizapride is an antagonist of dopamine receptor. Alizapride can be used in human digestive disorders which is a potent antiemetic [1] [3].

Formula: C₁₆H₂₁N₅O₂

Color and Shape: Solid

Molecular weight: 315.37

Ref: TM-T60813

Alizapride

CAS: 59338-93-1

Alizapride is a pharmaceutical preparation that is used for the treatment of infectious diseases and cancer. It is a prodrug that is converted in vivo to alizapridine, its active form. Alizapride has been shown to be effective in the treatment of emetogenic chemotherapy-induced vomiting and nausea. This drug also has minimal toxicity and low solubility in water, which makes it suitable for intravenous administration. Alizapride is broken down into metabolites that are excreted through the urine. The metabolite levels can be determined by a two-step liquid chromatography tandem mass spectrometry (LC-MS/MS) method using urine samples as a matrix.

Formula: C₁₆H₂₂ClN₅O₂

Purity: Min. 95%

Molecular weight: 351.8 g/mol

Ref: 3D-JCA33893