CAS 5939-37-7

7-Hydroxymethotrexate

Description:

7-Hydroxymethotrexate is a derivative of methotrexate, a well-known antimetabolite and chemotherapeutic agent primarily used in the treatment of certain cancers and autoimmune diseases. This compound is characterized by the presence of a hydroxyl group at the 7-position of the methotrexate structure, which alters its pharmacological properties compared to its parent compound. It exhibits similar mechanisms of action, primarily inhibiting dihydrofolate reductase, thereby interfering with DNA synthesis and cell proliferation. The presence of the hydroxyl group can influence its solubility, stability, and biological activity. 7-Hydroxymethotrexate is often studied for its potential therapeutic benefits and side effects, as well as its role in the metabolism of methotrexate in the body. Its CAS number, 5939-37-7, is a unique identifier that facilitates the tracking and study of this compound in scientific literature and databases. Overall, 7-Hydroxymethotrexate represents an important area of research in pharmacology and medicinal chemistry, particularly in optimizing cancer treatment regimens.

Formula: C₂₀H₂₂N₈O₆

InChI: InChI=1S/C20H22N8O6/c1-28(8-12-18(32)26-16-14(23-12)15(21)25-20(22)27-16)10-4-2-9(3-5-10)17(31)24-11(19(33)34)6-7-13(29)30/h2-5,11H,6-8H2,1H3,(H,24,31)(H,29,30)(H,33,34)(H5,21,22,25,26,27,32)/t11-/m0/s1

InChI key: InChIKey=HODZDDDNGRLGSI-NSHDSACASA-N

SMILES: NC1=C2C(NC(=O)C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=NC(N)=N1

Synonyms:

• 7-Hydroxymethotrexate
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2,4-diamino-7-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2,4-diamino-7-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• N-[(4-{[(2,4-diamino-7-oxo-7,8-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]-L-glutamic acid
• N-[(4-{[(2,4-diamino-7-oxo-7,8-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]glutamic acid
• N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• NSC 380962
• N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
• L-Glutamic acid, N-[4-[[(2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2,4-diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-

7-Hydroxymethotrexate

CAS: 5939-37-7

7-Hydroxymethotrexate

Purity: ≥95%

Molecular weight: 470.44g/mol

Ref: 54-BUP00611

7-Hydroxymethotrexate

CAS: 5939-37-7

7-Hydroxymethotrexate, major Methotrexate metabolite, inhibits dihydrofolate reductase and DNA synthesis by blocking folic acid conversion.

Formula: C₂₀H₂₂N₈O₆

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 470.44

Ref: TM-T20339

7-Hydroxy Methotrexate Trisodium Salt

CAS: 5939-37-7

Formula: C₂₀H₁₉N₈O₆·3Na

Color and Shape: Yellow Solid

Molecular weight: 467.42 3*22.99

Ref: 4Z-M-7011

7-Hydroxy Methotrexate-d3 Ammonium Salt

Controlled Product

CAS: 432545-62-5, 5939-37-7

Applications 7-Hydroxy Methotrexate-d3 is a deuterated metabolite of Methotrexate, which is used as a antineoplastic and antirheumatic.

Formula: C₂₀H₂₂D₃N₉O₆

Color and Shape: Neat

Molecular weight: 490.49

Ref: TR-H945928

7-Hydroxy Methotrexate Ammonium

Controlled Product

CAS: 5939-37-7

Applications 7-Hydroxy Methotrexate Ammonium Salt is a metabolite of Methotrexate (M260675), which is used as an antineoplastic and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₀H₂₂N₈O₆·NH₃

Color and Shape: Yellow To Brown

Molecular weight: 487.47

Ref: TR-H945926

7-Hydroxy Methotrexate

CAS: 5939-37-7

Formula: C₂₀H₂₂N₈O₆

Molecular weight: 470.45

Ref: ST-EA-CP-M12031

7-HYDROXY METHOTREXATE

CAS: 5939-37-7

Formula: C₂₀H₂₂N₈O₆

Purity: 98%

Molecular weight: 470.4387

Ref: IN-DA00E8VH