CAS 59401-28-4

alpha(1)-mating factor from saccharomy-ces cerevisiae

Description:

Alpha(1)-mating factor, also known as alpha-factor, is a peptide pheromone produced by the yeast Saccharomyces cerevisiae, specifically by alpha mating type cells. This signaling molecule plays a crucial role in the yeast's mating process by facilitating communication between different mating types (alpha and a). The structure of alpha-factor consists of a short chain of amino acids, typically comprising about 12 residues, which includes a unique cyclic structure that enhances its stability and biological activity. The pheromone binds to specific receptors on a cells, triggering a cascade of cellular responses that lead to mating and fusion of the two cell types. Alpha-factor is also utilized in various biotechnological applications, including yeast genetics and fermentation processes. Its CAS number, 59401-28-4, identifies it in chemical databases, aiding in research and development. Overall, alpha(1)-mating factor is essential for the reproductive cycle of yeast and serves as a model for studying cell signaling and communication in eukaryotic organisms.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

InChI: InChI=1/C82H114N20O17S/c1-45(2)34-61(98-76(112)63(38-49-41-89-56-17-9-7-15-53(49)56)99-77(113)64(39-50-42-87-44-91-50)96-71(107)54(84)37-48-40-88-55-16-8-6-14-52(48)55)74(110)93-57(25-27-68(85)104)72(108)97-62(35-46(3)4)75(111)95-59(18-10-11-30-83)80(116)101-31-12-19-66(101)78(114)90-43-70(106)92-60(26-28-69(86)105)81(117)102-32-13-20-67(102)79(115)94-58(29-33-120-5)73(109)100-65(82(118)119)36-47-21-23-51(103)24-22-47/h6-9,14-17,21-24,40-42,44-46,54,57-67,88-89,103H,10-13,18-20,25-39,43,83-84H2,1-5H3,(H2,85,104)(H2,86,105)(H,87,91)(H,90,114)(H,92,106)(H,93,110)(H,94,115)(H,95,111)(H,96,107)(H,97,108)(H,98,112)(H,99,113)(H,100,109)(H,118,119)/t54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=NCC(=N[C@@H](CCC(=N)O)C(=O)N1CCC[C@H]1C(=N[C@@H](CCSC)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)O)O)O)O)O)O)O)O)N=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](Cc1cnc[nH]1)N=C([C@H](Cc1c[nH]c2ccccc12)N)O)O)O

Synonyms:

• H-Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr-OH
• Mating Factor .alpha.
• a-Mating Factor, Yeast
• alpha1-Mating factor Saccharomyces cerevisiae
• L-tryptophyl-L-histidyl-L-tryptophyl-L-leucyl-L-glutaminyl-L-leucyl-L-lysyl-L-prolylglycyl-L-glutaminyl-L-prolyl-L-methionyl-L-tyrosine
• Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr

α-Mating Factor, yeast

CAS: 59401-28-4

alpha-Mating Factor, yeast

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Molecular weight: 1684.2

Ref: 02-J66502

Mating Factor α

CAS: 59401-28-4

Mating pheromone of mating type α cells of S. cerevisiae. This factor inhibits DNA synthesis, thereby preventing cell division of mating type a cells. The hydrophobic peptide binds to a class D G-protein-coupled receptor Ste2p.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: 98.4%

Color and Shape: White Powder

Molecular weight: 1684.01

Ref: 01-4003514

L-Tryptophyl-L-histidyl-L-tryptophyl-L-leucyl-L-glutaminyl-L-leucyl-L-lysyl-L-prolylglycyl-L-glutaminyl-L-prolyl-L-methionyl-L-tyrosine

CAS: 59401-28-4

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: 98%

Molecular weight: 1683.9714

Ref: IN-DA01EO0Y

α-Factor Mating Pheromone, yeast

CAS: 59401-28-4

Alpha factor mating pheromone is a peptide of 13 amino acids secreted by Saccharomyces cerevisiae α cells.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: 98%

Color and Shape: White Powder

Molecular weight: 1684

Ref: TM-TP1106

Alpha-Mating Factor

CAS: 59401-28-4

Alpha-Mating Factor is a peptide that belongs to the group of ligands. It has been shown to bind to the androgen receptor with high affinity and act as an activator for this receptor. Alpha-Mating Factor is also able to bind to the beta-adrenergic receptor. This protein has been shown to have ion channel activity, which may be due to its inhibition of potassium channels. Alpha-Mating Factor is used in research as a tool for studying cell biology and cell signalling pathways.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: Min. 95%

Molecular weight: 1,684 g/mol

Ref: 3D-PMF-4076-V

α-Factor

CAS: 59401-28-4

The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle, this allows the opposite mating type cells to synchronise. Alpha factor mating pheromone induces the expression of mating genes, changes in nuclear architecture, and polarizes growth toward the mating partner. STE2 encodes the alpha factor pheromone transmembrane G-protein coupled receptor (GPCR) found on mating-type-A cells in yeast. Alpha factor binds Ste2 and activates prototypic mitogen-activated protein kinase (MAPK) cascade. The dose of pheromone exposure differentially activates the MAPK Fus3 for alternate effects. A high dose of alpha factor leads to growth arrest and schmooing formation for mating, a lower dose causes elongated cell growth.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,683.97 g/mol

Ref: 3D-CRB1000148

Mating factor α trifluoroacetate

CAS: 59401-28-4

Mating factor α trifluoroacetate is a research tool with CAS No. 59401-28-4 that is used in Cell Biology, Pharmacology, and Ion channels. Mating factor α trifluoroacetate inhibits ligand binding to receptor by competing with the natural substrate for the active site. It has been shown to be an activator of ion channels, which allow ions to flow through the cell membrane. Mating factor α trifluoroacetate can also be used as a research tool in antibody production and protein interactions.

Formula: C₈₂H₁₁₄N₂₀O₁₇S

Purity: Min. 95%

Molecular weight: 1,684.01 g/mol

Ref: 3D-JCA40128

Mating Factor a trifluoroacetate salt

CAS: 59401-28-4

Please enquire for more information about Mating Factor a trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₈₂H₁₁₄N₂₀O₁₇S·xC₂HF₃O₂

Purity: Min. 95%

Molecular weight: 1,683.97 g/mol

Ref: 3D-FM108804