CAS 59467-64-0

7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-methanamine

Description:

7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-methanamine, with the CAS number 59467-64-0, is a chemical compound belonging to the benzodiazepine class, which is characterized by its bicyclic structure containing a benzene ring fused to a diazepine ring. This compound features a chlorine atom at the 7-position and a fluorophenyl group at the 5-position, contributing to its unique pharmacological properties. The presence of a methanamine group at the 2-position enhances its potential for biological activity. Benzodiazepines are known for their effects on the central nervous system, often exhibiting anxiolytic, sedative, and muscle relaxant properties. The specific substitution patterns in this compound may influence its binding affinity to GABA receptors, which are critical for its therapeutic effects. As with many benzodiazepines, the compound may also exhibit a range of side effects and interactions, necessitating careful consideration in pharmacological applications. Its synthesis and characterization would typically involve standard organic chemistry techniques, including purification and spectroscopic analysis to confirm its structure.

Formula: C₁₈H₁₃ClFN₃

InChI: InChI=1/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3

SMILES: Cc1ncc2CN=C(c3ccccc3F)c3cc(ccc3n12)Cl

Synonyms:

• 4H-imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
• 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin
• 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

[(2RS)-7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine

Controlled Product

CAS: 59467-64-0

Formula: C₁₆H₁₅ClFN₃

Color and Shape: Neat

Molecular weight: 303.76

Ref: 86-MM1106.07

2-Aminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine

Controlled Product

CAS: 59467-64-0

Applications An Intermediate for the synthesis of Midazolam.
References Walser, A., J. Org. Chem., 43, 936 (1978).

Formula: C₁₆H₁₅ClFN₃

Color and Shape: Neat

Molecular weight: 303.76

Ref: TR-A615355

Midazolam EP Impurity E

CAS: 59467-64-0

Formula: C₁₆H₁₅ClFN₃

Molecular weight: 303.8

Ref: ST-EA-CP-M85003

7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-methanamine

Controlled Product

CAS: 59467-64-0

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Formula: C₁₆H₁₅ClFN₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 303.76 g/mol

Ref: 3D-FC146870