CAS 59467-96-8

Midazolam hydrochloride

Description:

Midazolam hydrochloride is a medication belonging to the benzodiazepine class, primarily used for its sedative, anxiolytic, and amnesic properties. It is commonly administered in medical settings for procedural sedation, induction of anesthesia, and as an adjunct in various therapeutic protocols. The substance appears as a white to off-white crystalline powder, which is soluble in water and alcohol, facilitating its use in injectable formulations. Midazolam acts on the central nervous system by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to increased sedation and reduced anxiety. Its pharmacokinetics are characterized by rapid onset and a relatively short duration of action, making it suitable for short procedures. The hydrochloride salt form enhances its stability and solubility. As with other benzodiazepines, midazolam carries a risk of dependence and withdrawal symptoms, necessitating careful monitoring during use. It is classified as a controlled substance in many jurisdictions due to its potential for abuse and misuse.

Formula: C₁₈H₁₃ClFN₃·ClH

InChI: InChI=1S/C18H13ClFN3.ClH/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;/h2-9H,10H2,1H3;1H

InChI key: InChIKey=PLYSCVSCYOQVRP-UHFFFAOYSA-N

SMILES: CC=1N2C=3C(C(=NCC2=CN1)C4=C(F)C=CC=C4)=CC(Cl)=CC3.Cl

Synonyms:

• 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, hydrochloride (1:1)
• 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, monohydrochloride
• 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride (1:1)
• Hypnovel
• Midazolam Hydrochloride
• Ro 21-3981/003
• Rocam
• Syrpalta
• Versed

Midazolam.HCl

Controlled Product

CAS: 59467-96-8

Color and Shape: Neat

Ref: LP-MID-111-HC-10

Midazolam Hydrochloride

Controlled Product

CAS: 59467-96-8

Formula: C₁₈H₁₃ClFN₃·ClH

Color and Shape: Neat

Molecular weight: 362.23

Ref: 86-MM3605.00

Midazolam hydrochloride

Controlled Product

CAS: 59467-96-8

Midazolam hydrochloride is a sedative and minor tranquilizer that has minimal toxicity. It is used for the induction of general anesthesia, as an adjunct to general anesthesia, and as preoperative medication. Midazolam hydrochloride is administered intravenously, intramuscularly, or orally. When administered intravenously, midazolam reaches peak levels in the blood within one minute and has a duration of action of one to two hours. Midazolam can be used with other drugs such as opiates and nitrous oxide to provide anesthesia. The chemical stability of midazolam in solutions is dependent on pH; it will not break down at physiologic pH levels (7.0-7.4).

Formula: C₁₈H₁₃ClFN₃•HCl

Molecular weight: 362.23 g/mol

Ref: 3D-M-5441

Midazolam hydrochloride

Controlled Product

CAS: 59467-96-8

Allosteric modulator of GABA(A) receptors

Formula: C₁₈H₁₃ClFN₃•HCl

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 362.23 g/mol

Ref: 3D-FM102963

Midazolam Hydrochloride CIV

Controlled Product

CAS: 59467-96-8

Alprazolam(inn), camazepam (inn), chlordiazepoxide (inn), clonazepam (inn), clorazepate & other heterocyclic compounds with nitro atom(s) only

Formula: C₁₈H₁₃ClFN₃·HCl

Color and Shape: Light Yellow Powder

Molecular weight: 361.05488

Ref: 45-1443602