CAS 59588-86-2

Alamethicin I

Description:

Alamethicin I is a peptide antibiotic derived from the fungus Trichoderma viride. It is characterized by its ability to form ion channels in biological membranes, which disrupts cellular homeostasis and leads to cell lysis. Alamethicin I consists of a sequence of amino acids that contribute to its amphipathic nature, allowing it to interact with lipid bilayers effectively. This compound exhibits antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, making it of interest for both research and potential therapeutic applications. Its mechanism of action involves the formation of transmembrane pores, which facilitate the passage of ions and small molecules, ultimately compromising the integrity of the target cell. Alamethicin I is also studied for its role in membrane biophysics and as a model for understanding ion channel behavior. Due to its specific structure and function, it serves as a valuable tool in biochemistry and pharmacology, particularly in the study of membrane dynamics and the development of new antimicrobial agents.

Formula: C₉₂H₁₅₀N₂₂O₂₅

Synonyms:

• Alamethicin(synthetic Trichoderma viride)
• Alamethicin F 30
• Alamethicin RF 30
• Alamethicin g
• Antibiotic U 22324
• L-Glutamamide,N-acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-a-glutamyl-N1-[1-(hydroxymethyl)-2-phenylethyl]-,(S)-

Alamethicin

CAS: 59588-86-2

A channel-forming ionophore that activates membrane enzymes

Formula: C₉₂H₁₅₀N₂₂O₂₅

Color and Shape: Powder, White to pale cream

Molecular weight: 1964.34

Ref: 02-J63829

Alamethicin

CAS: 59588-86-2

Alamethicin is a peptide that has been shown to have potent cytotoxic activity against cancer cells. It works by binding to the membrane of cancer cells and forming pores, which leads to cell death. Alamethicin has also been found to be an inhibitor of protein kinases, which are enzymes that play a critical role in the regulation of cell growth and division. This makes it a promising candidate for anticancer therapy. In addition, alamethicin analogs have been developed as potential medicinal agents for the treatment of various types of tumors. Studies have shown that alamethicin can induce apoptosis in human cancer cells, making it a promising therapeutic agent for cancer treatment.

Formula: C₉₂H₁₅₀N₂₂O₂₅

Purity: Min. 95%

Molecular weight: 1,964.3 g/mol

Ref: 3D-JCA58886