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CAS 59721-28-7

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Camostat

Description:
Camostat, with the CAS number 59721-28-7, is a synthetic serine protease inhibitor primarily known for its role in inhibiting the activity of the enzyme transmembrane serine protease 2 (TMPRSS2). This inhibition is significant in the context of viral infections, particularly in blocking the entry of certain viruses, including coronaviruses, into host cells. Camostat is characterized by its ability to modulate inflammatory responses and has been investigated for potential therapeutic applications in various conditions, including pancreatitis and fibrosis. The compound is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. Camostat exhibits a relatively low toxicity profile, making it a candidate for further research in antiviral therapies. Its mechanism of action involves competitive inhibition, where it binds to the active site of serine proteases, thereby preventing substrate access. Overall, Camostat represents a promising avenue for therapeutic intervention in diseases associated with dysregulated protease activity.
Formula:C20H22N4O5
InChI:InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23)
InChI key:InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N
SMILES:C(OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1)(=O)C2=CC=C(NC(=N)N)C=C2
Synonyms:
  • 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneaxetic acid 2-(dimethylamino)-oxoethyl ester
  • 4-{2-[2-(Dimethylamino)-2-Oxoethoxy]-2-Oxoethyl}Phenyl 4-[(Diaminomethylidene)Amino]Benzoate
  • Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester
  • Camostat
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Found 4 products.