CAS 59721-29-8

Camostat mesylate

Description:

Camostat mesylate is a synthetic serine protease inhibitor primarily known for its role in inhibiting the activity of the enzyme trypsin. It is characterized by its ability to modulate various physiological processes, particularly in the context of inflammatory diseases and viral infections. The compound is often studied for its potential therapeutic effects against conditions such as pancreatitis and fibrosis. Camostat mesylate has garnered attention for its possible efficacy against certain viral infections, including those caused by coronaviruses, due to its mechanism of action that may interfere with viral entry into host cells. In terms of physical properties, it is typically presented as a white to off-white crystalline powder, soluble in water and various organic solvents. The substance is administered orally and has a relatively short half-life, necessitating careful consideration of dosing regimens in clinical applications. Overall, camostat mesylate represents a promising candidate in pharmacological research, particularly in the fields of virology and inflammation.

Formula: C₂₀H₂₂N₄O₅·CH₄O₃S

InChI: InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

InChI key: InChIKey=FSEKIHNIDBATFG-UHFFFAOYSA-N

SMILES: C(OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1)(=O)C2=CC=C(NC(=N)N)C=C2.S(C)(=O)(=O)O

Synonyms:

• 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate
• Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1)
• Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, monomethanesulfonate
• Camostat mesylate
• Camostat monomethanesulfonate
• Foipan
• Foy 305
• Foy-S 980
• N-(diaminomethylidene)-4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilinium methanesulfonate

Camostat Mesylate

CAS: 59721-28-7, 59721-29-8

Formula: C₂₀H₂₂N₄O₅·CH₄O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 494.52

Ref: 3B-C2977

Camostat methanesulfate, 98%

CAS: 59721-29-8

An orally active synthetic serine protease inhibitor

Formula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Purity: 98%

Color and Shape: White to cream, Powder

Molecular weight: 494.52

Ref: 02-J62362

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate

Purity: ≥98%

Molecular weight: 494.52g/mol

Ref: 54-BUP17156

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate

Formula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Purity: 99.77% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 494.52g/mol

Ref: 54-BISN0316

Camostat mesylate

CAS: 59721-29-8

Formula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Purity: ≥ 98.0%

Color and Shape: White crystalline powder or crystals

Molecular weight: 494.52

Ref: 7W-GP4306

Camostat Mesylate

CAS: 59721-29-8

Formula: C₂₀H₂₂N₄O₅·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 398.42 96.10

Ref: 4Z-C-131001

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

Formula: C₂₁H₂₆N₄O₈S

Purity: 99.31% - 99.85%

Color and Shape: Crystalline Solid

Molecular weight: 494.52

Ref: TM-T2391

Camostat Mesilate RS

CAS: 59721-29-8

Color and Shape: White

Ref: 2K-1037000021

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate is an inhibitor of trypsin-like serine proteases such as trypsin, thrombin, plasmin, plasma kallikrein and urokinase-type plasminogen activator. Camostat mesylate has also been shown to inhibit trimming of the viral spike (S) protein in coronaviruses. Camostat mesylate inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.

Formula: C₂₀H₂₂N₄O₅•CH₄O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 494.52 g/mol

Ref: 3D-FC19641

Camostat mesylate - Bio-X ™

CAS: 59721-29-8

Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.

Formula: C₂₀H₂₂N₄O₅•CH₄O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 494.52 g/mol

Ref: 3D-BC164270

Camostat Mesilate

CAS: 59721-29-8

Camostat mesilate is a prodrug that is metabolized to the active form, pemastatin. It is used for the treatment of bowel disease and squamous cell carcinoma. Camostat mesilate inhibits the TNF-α receptor by binding to its response element in vitro and in vivo. The biological properties of camostat mesilate are due to its ability to inhibit TNF-α production by binding to the TNF-α receptor, thereby preventing activation of transcription factors such as nuclear factor kappa B (NFκB). In vitro assays have shown that camostat mesilate induces apoptosis in human carcinoma cell lines through inhibition of growth factor-β1. This drug has also been shown to be effective in treating viral infections, including HIV and herpes zoster.

Formula: C₂₀H₂₂N₄O₅•CH₃SO₃H

Purity: Min. 95%

Molecular weight: 494.5 g/mol

Ref: 3D-ISP-3606-PI

4-(2-(2-(Dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate

CAS: 59721-29-8

Purity: 99%

Molecular weight: 494.519989

Ref: 10-F868964

Camostat Mesylate-D4

Controlled Product

CAS: 59721-29-8

Applications Camostat mesylate-D4 is a labelled analogue of Camostat mesylate (C150300).

Formula: C₂₀H₁₈D₄N₄O₅•CH₄O₃S

Color and Shape: Neat

Molecular weight: 402.44 + 96.11

Ref: TR-C150303

Camostat Mesylate-D6

Controlled Product

CAS: 59721-29-8

Formula: C₂₀H₁₆D₆N₄O₅•CH₃SO₃H

Color and Shape: Neat

Molecular weight: 500.56

Ref: TR-C150302

Camostat Mesylate

Controlled Product

CAS: 59721-29-8

Formula: C₂₀H₂₂N₄O₅·CH₄O₃S

Color and Shape: Neat

Molecular weight: 494.52

Ref: TR-C150300