CAS 59729-37-2

Fexinidazole

Description:

Fexinidazole is an investigational drug primarily studied for its potential use in treating human African trypanosomiasis, also known as sleeping sickness, caused by the parasite Trypanosoma brucei. It is characterized as a nitroimidazole compound, which is a class of drugs known for their antimicrobial properties. Fexinidazole exhibits a broad spectrum of activity against various strains of the parasite, making it a promising candidate for treatment, particularly in its oral formulation. The compound works by inhibiting the synthesis of nucleic acids in the parasite, ultimately leading to its death. Fexinidazole has been noted for its favorable pharmacokinetic profile, including good oral bioavailability and a manageable safety profile in clinical trials. Its development represents a significant advancement in the treatment of a disease that has historically been challenging due to the limited availability of effective therapies. As of the latest updates, fexinidazole has received regulatory approval in some regions, marking a crucial step forward in addressing this neglected tropical disease.

Formula: C₁₂H₁₃N₃O₃S

InChI: InChI=1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3

InChI key: InChIKey=MIWWSGDADVMLTG-UHFFFAOYSA-N

SMILES: C(OC1=CC=C(SC)C=C1)C=2N(C)C(N(=O)=O)=CN2

Synonyms:

• 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole
• 1-Methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
• 1-Methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole
• 1-methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole
• 1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-
• Fexinidazol
• Fexinidazol [INN-Spanish]
• Fexinidazole [INN]
• Fexinidazolum
• Fexinidazolum [INN-Latin]
• Hoe 239
• Unii-306Erl82Ir
• Fexinidazole
• HOE-239;HOE239;HOE 239

Fexinidazole

CAS: 59729-37-2

Formula: C₁₂H₁₃N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 279.3149

Ref: IN-DA00ECDO

1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole

CAS: 59729-37-2

1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole

Purity: 98%

Molecular weight: 279.31g/mol

Ref: 54-OR1026635

Fexinidazole

CAS: 59729-37-2

Fexinidazole

Purity: ≥98%

Molecular weight: 279.31g/mol

Ref: 54-BUP15593

Fexinidazole

CAS: 59729-37-2

Fexinidazole, an antiparasitic, targets T. cruzi, T. foetus, T. vaginalis, E. histolytica, T. brucei, L. donovani. Active forms: sulfoxide, sulfone.

Formula: C₁₂H₁₃N₃O₃S

Purity: 99.67% - 99.87%

Color and Shape: Solid

Molecular weight: 279.31

Ref: TM-T2112

Fexinidazole

CAS: 59729-37-2

Formula: C₁₂H₁₃N₃O₃S

Color and Shape: Neat

Ref: TR-F322575

1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole

CAS: 59729-37-2

Formula: C₁₂H₁₃N₃O₃S

Purity: ≥99%

Color and Shape: Solid

Molecular weight: 279.31

Ref: 10-F242465

1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole

CAS: 59729-37-2

1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole is a nitroheterocyclic compound that belongs to the group of antimicrobial agents. It has been shown to be active against Leishmania and is used in combination therapy with melarsoprol and sesquiterpene lactones. 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole inhibits the growth of bacteria by interfering with their electron transport system, which may lead to cell death. 1-Methyl-2-[(4-(methylthio)phenoxy)methyl]-5nitro -1H imidazole also has pharmacokinetic properties that are similar to those of fexinidazole, which makes it suitable as an experimental model for this drug's effects on humans.

Formula: C₁₂H₁₃N₃O₃S

Purity: Min. 95%

Molecular weight: 279.31 g/mol

Ref: 3D-JCA72937