CAS 597562-32-8

LL-37

Description:

LL-37 is a human cathelicidin antimicrobial peptide (CAMP) that plays a crucial role in the innate immune response. It is composed of 37 amino acids and is derived from the precursor protein hCAP-18, which is expressed in various tissues, including skin and mucosal surfaces. LL-37 exhibits a broad spectrum of antimicrobial activity against bacteria, fungi, and viruses, making it an essential component of the host defense system. Its mechanism of action involves disrupting microbial membranes, leading to cell lysis. Additionally, LL-37 has immunomodulatory properties, influencing inflammation and wound healing processes. The peptide is also known to exhibit chemotactic activity, attracting immune cells to sites of infection or injury. Due to its multifaceted roles, LL-37 is of significant interest in research related to infectious diseases, inflammation, and potential therapeutic applications. Its CAS number, 597562-32-8, is used for identification in chemical databases and regulatory contexts.

Synonyms:

• H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
• antibacterial protein LL-37 amide

LL-37 amide

CAS: 597562-32-8

LL-37 amide is an antimicrobial peptide with angiogenic activity.

Formula: C₂₀₅H₃₄₁N₆₁O₅₂

Purity: 98.6%

Color and Shape: White Lyophilisate

Molecular weight: 4492.34

Ref: 01-4046855

LL-37 amide

CAS: 597562-32-8

LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also regulates many aspects of the innate immune system and overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis, making LL-37 the most studied form of the human cathelicidin peptides.More recently, studies have shown that LL-37 binds to SARS-CoV-2 S protein and inhibits binding to its receptor hACE2, which may inhibit viral entry into the cell. LL-37 is upregulated by vitamin D, therefore this may be one mode of action for the positive outcomes seen with vitamin D treatment for Covid-19.

Formula: C₂₀₅H₃₄₁N₆₁O₅₂

Molecular weight: 4,493.3 g/mol

Ref: 3D-CRB1000864

LL-37 amide trifluoroacetate

CAS: 597562-32-8

Please enquire for more information about LL-37 amide trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₀₅H₃₄₁N₆₁O₅₂•(C₂HF₃O₂)x

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 4,492.28 g/mol

Ref: 3D-FL109760