CAS 5976-55-6

Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, 17-acetate, (17β)-

Description:

Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, 17-acetate, (17β)-, commonly known as a synthetic estrogen, is a derivative of estradiol, characterized by its structural modifications that enhance its biological activity. This compound features a steroid backbone with a hydroxyl group at the 17 position, a methoxy group at the 3 position, and an acetate group at the 17β position, which contributes to its lipophilicity and potential for oral bioavailability. It exhibits estrogenic activity, binding to estrogen receptors and influencing various physiological processes, including reproductive functions and secondary sexual characteristics. The compound is often utilized in hormone replacement therapy and contraceptive formulations due to its ability to mimic natural estrogen. Its chemical stability, solubility in organic solvents, and specific pharmacokinetic properties make it a valuable compound in both therapeutic and research contexts. Safety and efficacy profiles are critical for its application, necessitating thorough evaluation in clinical settings.

Formula: C₂₁H₂₈O₃

InChI: InChI=1S/C21H28O3/c1-13(22)24-20-9-8-19-18-6-4-14-12-15(23-3)5-7-16(14)17(18)10-11-21(19,20)2/h5,7,12,17-20H,4,6,8-11H2,1-3H3/t17-,18-,19+,20+,21+/m1/s1

InChI key: InChIKey=FMNPCVNWRFPDCA-MJCUULBUSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC)=CC4)(CC1)[H])[H])(CC[C@@H]2OC(C)=O)[H]

Synonyms:

• 17β-Acetoxy-3-methoxyestra-1,3,5(10)-triene
• 3-Methoxy-1,3,5(10)-estratrien-17β-ol acetate
• 3-Methoxy-17β-acetoxyestra-1,3,5(10)-triene
• 3-Thiazolidinepropanoic acid, 5-[(2,5-dimethoxyphenyl)methylene]-4-oxo-2-thioxo-, (5Z)-
• Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, 17-acetate, (17β)-
• Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, acetate, (17β)-
• Estra-1,3,5(10)-trien-17β-ol, 3-methoxy-, acetate
• Estradiol 17-acetate 3-methyl ether
• Estradiol 3-methyl ether 17-acetate
• 3-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid

17-O-Acetyl-3-O-methyl 17β-Estradiol

Controlled Product

CAS: 5976-55-6

Applications Estradiol derivative. Used in the preparation of hydroxy steroid dehydrogenese inhibitors.
References Goldman, A. et al.: Enzymology 315, 233 (1973)

Formula: C₂₁H₂₈O₃

Color and Shape: Neat

Molecular weight: 328.45

Ref: TR-A186830

17-O-Acetyl-3-O-methyl 17β-Estradiol

CAS: 5976-55-6

Formula: C₂₁H₂₈O₃

Molecular weight: 328.45

Ref: ST-EA-CP-E3035