CAS 5976-67-0

2-Methoxyestradiol-3-O-methyl ether

Description:

2-Methoxyestradiol-3-O-methyl ether, with the CAS number 5976-67-0, is a synthetic derivative of estradiol, a primary female sex hormone. This compound is characterized by the presence of a methoxy group at the 2-position and a methyl ether at the 3-position of the estradiol backbone. It exhibits estrogenic activity, although it is generally considered to have a lower potency compared to estradiol itself. The compound has garnered interest in research due to its potential therapeutic applications, particularly in cancer treatment, as it may inhibit tumor growth and angiogenesis. Additionally, 2-Methoxyestradiol-3-O-methyl ether has been studied for its anti-inflammatory and neuroprotective properties. Its solubility in organic solvents and limited solubility in water are notable physical characteristics, which can influence its bioavailability and pharmacokinetics. As with many steroid derivatives, its biological effects are mediated through interactions with estrogen receptors, making it a subject of interest in both pharmacology and medicinal chemistry.

Formula: C₂₀H₂₈O₃

InChI: InChI=1S/C20H28O3/c1-20-9-8-13-14(16(20)6-7-19(20)21)5-4-12-10-17(22-2)18(23-3)11-15(12)13/h10-11,13-14,16,19,21H,4-9H2,1-3H3/t13-,14+,16-,19-,20-/m0/s1

InChI key: InChIKey=AVCFXYYRWRZONV-BKRJIHRRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC)=C(OC)C4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• 2-Methoxy-17β-estradiol 3-methyl ether
• Estra-1,3,5(10)-trien-17-ol, 2,3-dimethoxy-, (17β)-
• (17β)-2,3-Dimethoxyestra-1,3,5(10)-trien-17-ol
• 2-Hydroxyestradiol 2,3-dimethyl ether
• Estra-1,3,5(10)-trien-17β-ol, 2,3-dimethoxy-

2-Methoxyestradiol-3-O-methyl Ether

Controlled Product

CAS: 5976-67-0

Formula: C₂₀H₂₈O₃

Color and Shape: Neat

Molecular weight: 316.435

Ref: TR-M350065