CAS 59787-61-0

Cyclosporin C

Description:

Cyclosporin C is a cyclic polypeptide that belongs to the class of immunosuppressive agents, primarily derived from the fungus Tolypocladium inflatum. It is structurally similar to cyclosporin A but exhibits distinct pharmacological properties. Cyclosporin C is characterized by its ability to inhibit T-cell activation and proliferation, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. The compound is lipophilic, which influences its absorption and distribution in biological systems. It has a relatively low solubility in water but is soluble in organic solvents, which is important for its formulation in pharmaceutical preparations. Cyclosporin C's mechanism of action involves binding to cyclophilin, leading to the inhibition of calcineurin, a critical enzyme in T-cell signaling. This results in decreased production of interleukin-2 and other cytokines, thereby modulating the immune response. While it shares some therapeutic applications with cyclosporin A, cyclosporin C may have different side effect profiles and efficacy, warranting further investigation in clinical settings.

Formula: C₆₂H₁₁₁N₁₁O₁₃

InChI: InChI=1/C62H111N11O13/c1-25-26-27-39(14)52(76)51-56(80)66-49(42(17)74)60(84)67(18)32-47(75)68(19)43(28-33(2)3)55(79)65-48(37(10)11)61(85)69(20)44(29-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)45(30-35(6)7)58(82)71(22)46(31-36(8)9)59(83)72(23)50(38(12)13)62(86)73(51)24/h25-26,33-46,48-52,74,76H,27-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,79)(H,66,80)/b26-25+/t39-,40+,41-,42-,43+,44+,45+,46+,48+,49+,50+,51+,52-/m1/s1

Synonyms:

• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-hydroxyethyl]-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 7-L-Threoninecyclosporin A
• WF-3484
• Cyclosporin C, >=95%
• CYCLOSPORIN C
• Cyclosporine IMpurity-C
• (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Thr-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• 7-L-Threoninecyclosporin A, WF 3484
• 7-Threonine-cyclosporin A
• Thr2-cyclosporine

Cyclosporin C

CAS: 59787-61-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 1218.6106

Ref: IN-DA00IALX

Cyclosporin C

CAS: 59787-61-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Molecular weight: 1218.63

Ref: 4Z-PC-545

Cyclosporin C

CAS: 59787-61-0

Cyclosporin C

Purity: ≥98%

Molecular weight: 1218.61g/mol

Ref: 54-BUP00603

Cyclosporin C

CAS: 59787-61-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: 95%~99%

Molecular weight: 1218.63

Ref: BP-BP0439

Cyclosporin C

CAS: 59787-61-0

Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi.

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: 98.77%

Color and Shape: Less To Off-White Crystalline Solid Colorless To Off-White Crystalline Solid

Molecular weight: 1218.61

Ref: TM-T19971

Cyclosporin C

CAS: 59787-61-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Molecular weight: 1218.6

Ref: ST-EA-CP-C162008

Cyclosporin C

Controlled Product

CAS: 59787-61-0

Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: >80%

Color and Shape: Neat

Molecular weight: 1218.61

Ref: TR-C988905

Cyclosporin C

CAS: 59787-61-0

Aurora kinase inhibitor

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 1,218.6 g/mol

Ref: 3D-FC20755