CAS 5980-02-9

Vindolinine

Description:

Vindolinine is an alkaloid derived from the plant Vinca rosea, commonly known as the Madagascar periwinkle. It is characterized by its complex structure, which includes a tetracyclic framework. Vindolinine exhibits a range of biological activities, particularly in the field of pharmacology, where it has been studied for its potential anti-cancer properties. The compound is known to interact with various biological targets, influencing cellular processes such as mitosis and apoptosis. Its mechanism of action often involves the disruption of microtubule dynamics, similar to other vinca alkaloids. Vindolinine is typically found in low concentrations in plant extracts, necessitating advanced extraction and purification techniques for study. Additionally, it has been investigated for its effects on the central nervous system and its potential use in treating other diseases. As with many alkaloids, caution is advised due to possible toxicity and side effects associated with its use. Overall, vindolinine represents a significant area of interest in natural product chemistry and medicinal research.

Formula: C₂₁H₂₄N₂O₂

InChI: InChI=1S/C21H24N2O2/c1-13-19-8-5-10-23-11-9-20(18(19)23)14-6-3-4-7-16(14)22-21(13,20)15(12-19)17(24)25-2/h3-8,13,15,18,22H,9-12H2,1-2H3/t13-,15+,18+,19+,20-,21-/m1/s1

InChI key: InChIKey=JSLDLCGKZDUQSH-SBDPWIONSA-N

SMILES: C(OC)(=O)[C@H]1[C@@]23[C@@]4([C@@]5([C@]([C@H]2C)(C1)C=CCN5CC4)[H])C=6C(N3)=CC=CC6

Synonyms:

• (-)-Vindolinine
• (19R)-Vindolinine
• 2,20-Cycloaspidospermidine-3-Carboxylic Acid, 6,7-Didehydro-, Methyl Ester
• 2,20-Cycloaspidospermidine-3-carboxylic acid, 6,7-didehydro-, methyl ester, (2α,3β,5α,12R,19α,20R)-
• 2,20-Cycloaspidospermidine-3-carboxylic acid, 6,7-didehydro-, methyl ester, (2α,3β,5α,12β,19α,20R)-
• 6H,13aH-3a,5a-Methano-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid, 4,5,11,12-tetrahydro-14-methyl-, methyl ester, [3aR-(3aα,5β,5aα,10bR*,13aα,14R*)]-

Vindolinine

CAS: 5980-02-9

Vindolinine is a natural product from Catharanthus roseus (L.) G. Don.

Formula: C₂₁H₂₄N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 336.435

Ref: TM-TN2300

Vindolinine

CAS: 5980-02-9

Formula: C₂₁H₂₄N₂O₂

Purity: 95%~99%

Molecular weight: 336.435

Ref: BP-BP3630

Vindolinine

CAS: 5980-02-9

Vindolinine is a nucleophilic alkaloid that inhibits the uptake of glucose by pancreatic cells. It has been shown to be effective in the treatment of cancer and diabetes. Vindolinine is a monoterpenoid indole alkaloid that is found in plants belonging to the family Apocynaceae. Magnetic resonance spectroscopy has revealed that vindolinine is structurally similar to other alkaloids, such as vincamine, which are used for the treatment of diabetes. In tissue culture experiments, vindolinine has been shown to inhibit fatty acid synthesis and increase fatty acid oxidation.

Purity: Min. 95%

Ref: 3D-FV74460