CAS 59865-13-3

Cyclosporine A

Description:

Cyclosporine A is a cyclic polypeptide composed of 11 amino acids, primarily known for its immunosuppressive properties. It is produced by the fungus Tolypocladium inflatum and is widely used in clinical settings, particularly in organ transplantation and autoimmune diseases, to prevent organ rejection and manage conditions like rheumatoid arthritis. The substance functions by inhibiting the activation of T-lymphocytes, thereby reducing the immune response. Cyclosporine A is lipophilic, which affects its absorption and distribution in the body; it is typically administered orally or intravenously. Its pharmacokinetics can be influenced by various factors, including food intake and concurrent medications, necessitating careful monitoring of blood levels to avoid toxicity. Adverse effects may include nephrotoxicity, hypertension, and increased susceptibility to infections. Due to its complex interactions and side effects, cyclosporine A requires careful management and dosage adjustments based on individual patient response and clinical context.

Formula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key: PMATZTZNYRCHOR-CGLBZJNRSA-N

SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Synonyms:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: >97.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 1,202.64

Ref: 3B-C2408

Cyclosporin A, 99+%

CAS: 59865-13-3

Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 99+%

Color and Shape: White, Powder or crystals or crystalline powder

Molecular weight: 1202.61

Ref: 02-J63191

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

CAS: 59865-13-3

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

Color and Shape: Added

Ref: 41-Y0002292

CICLOSPORIN CRS

CAS: 59865-13-3

CICLOSPORIN CRS

Color and Shape: Added

Ref: 41-C2163000

Cyclosporine

CAS: 59865-13-3

Lactams, nesoi

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: White Powder

Molecular weight: 1201.84137

Ref: 45-1158504

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1202.6112

Ref: IN-DA00IKI7

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 99.00% - 99.94%

Color and Shape: White Solid

Molecular weight: 1202.61

Ref: TM-T0945

Cyclosporine A from Beauveria Nivea

CAS: 59865-13-3

Cyclosporine A from Beauveria Nivea

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 99%

Color and Shape: White Solid

Molecular weight: 1202.61124

Ref: 54-BITP1533

Cyclosporin A, USP grade

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: ≤ 0.7%

Color and Shape: Colourless crystals, or white to almost white powder

Molecular weight: 1202.61

Ref: 7W-GA2331

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: ≥98%

Molecular weight: 1202.61

Ref: 54-BUP14762

Cyclosporin A-13C2-d4 (Cyclosporine-13C2-d4)

CAS: 59865-13-3

Formula: C₆₀₁₃C₂H₁₀₇D₄N₁₁O₁₂

Molecular weight: 1208.64

Ref: 4Z-PC-5441

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 98.5 - 101.5 % (dried basis)

Color and Shape: Colourless crystals, or white to almost white powder

Molecular weight: 1202.61

Ref: 7W-GA6323

Cyclosporin A (Cyclosporine)

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: White To Off-White Solid

Molecular weight: 1202.64

Ref: 4Z-PC-541

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 97%

Color and Shape: Solid-Powder

Molecular weight: 1202.62

Ref: 54-BI4559

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: 95%~99%

Molecular weight: 1202.64

Ref: BP-BP0438

Ciclosporin

Controlled Product

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1202.61

Ref: 86-MM0241.00

Cyclosporin A

Controlled Product

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1202.61

Ref: 04-C11836300

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1202.61

Ref: TR-C988900

Cyclosporin A-d4 (Major)

Controlled Product

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₀₇D₄N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Controlled Product

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1208.62

Ref: TR-C988901