CAS 59865-15-5

(3S,6S,9R,12R,15S,18S,21S,24S,30S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,

Description:

The chemical substance with the name "(3S,6S,9R,12R,15S,18S,21S,24S,30S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26" and CAS number "59865-15-5" is a complex organic compound characterized by its extensive polycyclic structure and multiple chiral centers. This compound features a large number of methyl and propyl substituents, contributing to its hydrophobic nature and potentially influencing its solubility and interaction with biological membranes. The presence of hydroxy and ethyl groups suggests it may exhibit some degree of polarity, which could affect its reactivity and biological activity. Additionally, the multiple azacycloalkane units indicate potential applications in medicinal chemistry, particularly in drug design or as a scaffold for further chemical modifications. Its intricate stereochemistry may also play a crucial role in determining its biological function and pharmacokinetics. Overall, this compound exemplifies the complexity often found in synthetic organic chemistry and its potential implications in various fields.

Formula: C₆₂H₁₁₃N₁₁O₁₂

InChI: InChI=1/C62H113N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h34-47,49-52,75H,25-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t40-,41+,42-,43+,44+,45+,46-,47+,49+,50+,51?,52-/m1/s1

Dihydrocyclosporin A

CAS: 59865-15-5

Dihydrocyclosporin A

Purity: ≥95%

Molecular weight: 1204.63g/mol

Ref: 54-BUP03555

Ciclosporin EP Impurity B (Dihydrocyclosporin A)

CAS: 59865-15-5

Formula: C₆₂H₁₁₃N₁₁O₁₂

Color and Shape: Off-White Solid

Molecular weight: 1204.65

Ref: 4Z-PC-5423

Dihydrocyclosporin A

CAS: 59865-15-5

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A.

Formula: C₆₂H₁₁₃N₁₁O₁₂

Purity: 95% - 99.50%

Color and Shape: Solid

Molecular weight: 1204.63

Ref: TM-T31467

Dihydro Cyclosporin A

Controlled Product

CAS: 59865-15-5

Applications A Cyclosporin A (C988900) analog, an immunosuppressant.
References Emmer, G., et al.: J. Med. Chem., 37, 1918 (1994), High, K., et al.: J. Biol. Chem., 269, 9105 (1994),

Formula: C₆₂H₁₁₃N₁₁O₁₂

Color and Shape: White

Molecular weight: 1204.63

Ref: TR-D448865

Dihydrocyclosporin A

CAS: 59865-15-5

Dihydrocyclosporin A is an immunosuppressant, which is a cyclic undecapeptide derived from fungal metabolites, specifically from the soil fungus Tolypocladium inflatum. This compound functions through the inhibition of calcineurin, which is a crucial phosphatase involved in the activation of T-cells. By binding to the intracellular protein cyclophilin, Dihydrocyclosporin A forms a complex that inhibits calcineurin activity, subsequently blocking the transcription of interleukin-2 and other cytokines essential for T-cell proliferation.

Formula: C₆₂H₁₁₃N₁₁O₁₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 1,204.63 g/mol

Ref: 3D-FD21913

Dihydro Cyclosporin A

CAS: 59865-15-5

Formula: C₆₂H₁₁₃N₁₁O₁₂

Molecular weight: 1204.65

Ref: ST-EA-CP-C162002