CAS 599-79-1: Sulfasalazine
Description:Sulfasalazine is a medication primarily used in the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, as well as rheumatoid arthritis. It is a sulfonamide compound that consists of a 5-aminosalicylic acid (5-ASA) moiety linked to sulfapyridine via an azo bond. This structure allows it to exert anti-inflammatory effects in the intestines while minimizing systemic absorption. Sulfasalazine is typically administered orally and is known for its ability to reduce inflammation by inhibiting the production of pro-inflammatory cytokines and leukotrienes. The drug is generally well-tolerated, though it can cause side effects such as gastrointestinal disturbances, headache, and hypersensitivity reactions. Monitoring for potential adverse effects, including liver function and blood counts, is recommended during treatment. Additionally, sulfasalazine may interact with other medications, necessitating careful management in patients receiving multiple therapies. Overall, it plays a significant role in managing chronic inflammatory conditions, contributing to improved quality of life for many patients.
Formula:C18H14N4O5S
InChI:InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
InChI key:InChIKey=NCEXYHBECQHGNR-UHFFFAOYSA-N
SMILES:O=C(O)C1=CC(N=NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CC=C3)=CC=C1O
- Synonyms:
- (3Z)-6-oxo-3-{[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazono}cyclohexa-1,4-diene-1-carboxylic acid
- 2-Hydroxy-5-((4-(N-(pyridin-2-yl)sulfamoyl)phenyl)diazenyl)benzoic acid
- 2-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]benzoic acid
- 2-Hydroxy-5-[[4-[(2-Pyridinylamino)Sulfonyl]Phenyl]Azo]Benzoic Acid
- 2-Hydroxy-5-{[4-(Pyridin-2-Ylsulfamoyl)Phenyl]Diazenyl}Benzoic Acid
- 2-hydroxy-5-{(E)-[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
- 5-(P-(2-Pyridylsulfamoyl)Phenylazo)Salicylic Acid
- 5-[4-(2-Pyridylsulfamyl)phenylazo]-2-hydroxybenzoic acid
- 5-[p-(2-Pyridylsulfamyl)phenylazo]salicylic acid
- 6-Oxo-3-{[4-(Pyridin-2-Ylsulfamoyl)Phenyl]Hydrazono}Cyclohexa-1,4-Diene-1-Carboxylic Acid
- See more synonyms
- Azopyrin
- Azopyrine
- Azulfidine
- Azulfidine EN
- Azulfin
- Benzoic acid, 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-
- Benzoic acid, 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]-
- Benzosulfa
- Colo-Pleon
- Nsc 203730
- Nsc 667219
- Reupirin
- Salazopyridin
- Salazopyrin
- Salazopyrine
- Salazosulfapiridina
- Salazosulfapyridin
- Salicylazosulfapyridine
- Salicylic acid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]-
- Salisulf
- Sulazine
- Sulfasalazin
- Sulfasalazine
- Sulphasalazine
![2-hydroxy-5-(2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl)benzoic acid](https://static.cymitquimica.com/products/10/thumb/F358095.jpg)
