CAS 59917-39-4: Vindesine sulfate
Description:Vindesine sulfate is a synthetic vinca alkaloid derived from the periwinkle plant, specifically used in cancer treatment. It functions primarily as an antineoplastic agent, inhibiting cell division by disrupting the mitotic spindle formation during cell division, which ultimately leads to apoptosis in rapidly dividing cancer cells. The compound is characterized by its ability to bind to tubulin, preventing the polymerization necessary for microtubule formation. Vindesine sulfate is typically administered intravenously and is known for its efficacy against various types of cancers, including lymphomas and solid tumors. Its chemical structure includes a complex ring system, contributing to its biological activity. Side effects may include myelosuppression, peripheral neuropathy, and gastrointestinal disturbances, which are common among chemotherapeutic agents. Due to its potent effects and potential toxicity, careful monitoring during treatment is essential. As with many chemotherapeutics, its use is often part of a combination therapy regimen to enhance efficacy and reduce the likelihood of resistance.
Formula:C43H55N5O7·H2O4S
InChI:InChI=1S/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4)/t25-,34+,35-,36-,39+,40-,41-,42+,43+;/m1./s1
InChI key:InChIKey=COFJBSXICYYSKG-FJFFLIEUSA-N
SMILES:O=C(OC)C1(C=2C=C3C(=CC2OC)N(C)C4C(O)(C(=O)N)C(O)C5(C=CCN6CCC34C65)CC)C=7NC=8C=CC=CC8C7CCN9CC(CC(O)(C9)CC)C1.O=S(=O)(O)O
- Synonyms:
- 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
- 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
- Dava
- Desacetylvinblastine amide sulfate
- Eldesine
- Eldisine
- Fildesin
- Lilly 99094
- Ly 099094
- Nsc 245467
- See more synonyms
- Vincaleukoblastin, 3-(Aminocarbonyl)-O-4-deacetyl-3-de(methoxycarbonyl)-, Sulfat (1:1) (Salz)
- Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1)
- Vincaleukoblastine, 3-(aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1)
- Vincaleukoblastine, 3-(aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt)
- Vindesine sulfate
- Xi Ai Ke Vial
- vinblastine, (aminocarbonyl)-3 O4-deacetylde(methoxycarbonyl)-3, sulfate (1:1) (sel)
- vincaleucoblastina, 3-(aminocarbonil)-O4-desacetil-3-des(metoxicarbonil)-, sulfato (1:1) (sal)
- vindesine sulphate
- methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate sulfate (1:1)
- Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt)
