CAS 59917-39-4

Vindesine sulfate

Description:

Vindesine sulfate is a synthetic vinca alkaloid derived from the periwinkle plant, specifically used in cancer treatment. It functions primarily as an antineoplastic agent, inhibiting cell division by disrupting the mitotic spindle formation during cell division, which ultimately leads to apoptosis in rapidly dividing cancer cells. The compound is characterized by its ability to bind to tubulin, preventing the polymerization necessary for microtubule formation. Vindesine sulfate is typically administered intravenously and is known for its efficacy against various types of cancers, including lymphomas and solid tumors. Its chemical structure includes a complex ring system, contributing to its biological activity. Side effects may include myelosuppression, peripheral neuropathy, and gastrointestinal disturbances, which are common among chemotherapeutic agents. Due to its potent effects and potential toxicity, careful monitoring during treatment is essential. As with many chemotherapeutics, its use is often part of a combination therapy regimen to enhance efficacy and reduce the likelihood of resistance.

Formula: C₄₃H₅₅N₅O₇·H₂O₄S

InChI: InChI=1S/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4)/t25-,34+,35-,36-,39+,40-,41-,42+,43+;/m1./s1

InChI key: InChIKey=COFJBSXICYYSKG-FJFFLIEUSA-N

SMILES: C(C)[C@@]12[C@]3([C@]4(C=5C(N(C)[C@]4([C@](C(N)=O)(O)[C@@H]1O)[H])=CC(OC)=C(C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@]9C[C@@](C6)(C[C@](CC)(O)C9)[H])CCN3CC=C2)[H].S(=O)(=O)(O)O

Synonyms:

• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• Dava
• Desacetylvinblastine amide sulfate
• Eldesine
• Eldisine
• Fildesin
• Lilly 99094
• Ly 099094
• Nsc 245467
• Vincaleukoblastin, 3-(Aminocarbonyl)-O-4-deacetyl-3-de(methoxycarbonyl)-, Sulfat (1:1) (Salz)
• Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1)
• Vincaleukoblastine, 3-(aminocarbonyl)-O⁴-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1)
• Vincaleukoblastine, 3-(aminocarbonyl)-O⁴-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt)
• Vindesine sulfate
• Xi Ai Ke Vial
• vinblastine, (aminocarbonyl)-3 O4-deacetylde(methoxycarbonyl)-3, sulfate (1:1) (sel)
• vincaleucoblastina, 3-(aminocarbonil)-O4-desacetil-3-des(metoxicarbonil)-, sulfato (1:1) (sal)
• vindesine sulphate
• methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate sulfate (1:1)

VINDESINE SULFATE CRS

CAS: 59917-39-4

VINDESINE SULFATE CRS

Formula: C₄₃H₅₇N₅O₁₁S

Color and Shape: Powder

Molecular weight: 852.0046

Ref: 41-V0500000

Vindesine (sulfate)

CAS: 59917-39-4

Formula: C₄₃H₅₇N₅O₁₁S

Purity: 98%

Color and Shape: Solid

Molecular weight: 852.0046

Ref: IN-DA01E4TE

Vindesine sulfate hydrate

CAS: 59917-39-4

Formula: C₄₃H₅₅N₅O₇·H₂SO₄·xH₂O

Molecular weight: 852.00 (anhydrous)

Ref: 7W-GP1189

Vindesine sulfate

CAS: 59917-39-4

Vindesine sulfate

Purity: ≥95%

Molecular weight: 852g/mol

Ref: 54-BUP00008

Vindesine sulfate

CAS: 59917-39-4

Formula: C₄₃H₅₅N₅O₇

Purity: 95%~99%

Molecular weight: 753.941

Ref: BP-BP1442

Vindesine

CAS: 59917-39-4

Formula: C₄₃H₅₅N₅O₇

Molecular weight: 753.94

Ref: 4Z-V-075001

Vindesine sulfate

CAS: 59917-39-4

Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.

Formula: C₄₃H₅₇N₅O₁₁S

Purity: 97.51%

Color and Shape: Amorphous Solid

Molecular weight: 852

Ref: TM-T22455

Vindesine sulfate - Bio-X ™

CAS: 59917-39-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₄₃H₅₇N₅O₁₁S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 852.01 g/mol

Ref: 3D-BV164524

Vindesine sulfate

CAS: 59917-39-4

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

Formula: C₄₃H₅₇N₅O₁₁S

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 852.01 g/mol

Ref: 3D-FV28697

Vindesine Sulfate Salt

Controlled Product

CAS: 59917-39-4

Stability Hygroscopic
Applications Vindesine Sulfate Salt is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic.
References Todd, G.C., et al.: Toxicol. Environ. Health 1, 843 (1976), Owellen, J.R., et al.: Biochem. Pharmacol., 26, 1213 (1977),

Formula: C₄₃H₅₅N₅O₇·H₂O₄S

Color and Shape: Neat

Molecular weight: 852.00

Ref: TR-V414550