CAS 60-02-6

Guanethidine sulfate

Description:

Guanethidine sulfate is a chemical compound primarily used as an antihypertensive agent. It is a quaternary ammonium salt derived from guanidine, characterized by its ability to inhibit the release of norepinephrine from sympathetic nerve endings, thereby reducing blood pressure. The compound is typically administered in its sulfate form, which enhances its solubility in water. Guanethidine sulfate is known for its relatively low oral bioavailability and is often given via injection. It has a moderate to high melting point and is stable under normal conditions, although it should be stored away from light and moisture to maintain its efficacy. The compound's mechanism of action involves the depletion of norepinephrine stores, leading to vasodilation and decreased peripheral resistance. While effective in managing hypertension, guanethidine sulfate may have side effects, including orthostatic hypotension and potential interactions with other medications. Due to these factors, its use has declined in favor of newer antihypertensive agents with improved safety profiles.

Formula: C₁₀H₂₂N₄H₂O₄S

InChI: InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

InChI key: InChIKey=YUFWAVFNITUSHI-UHFFFAOYSA-N

SMILES: S(=O)(=O)(O)O.C(CNC(=N)N)N1CCCCCCC1

Synonyms:

• 2-[2-(Azocan-1-Yl)Ethyl]Guanidine Sulfate (2:1)
• Azocine, guanidine deriv.
• Guanethidine Hemisulfate
• Guanethidine Sulfate 2:1
• Guanethidine sulfate
• Guanethidinesulfate
• Guanetidin sulfate
• Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (2:1)
• Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (2:1)
• Guethine
• Iporal
• Ismelin sulfate
• Isobarin
• NSC 29863
• Octadin
• Octadine
• Octatensin
• Oktadin
• Sanotensin

Guanethidine Hemisulfate

CAS: 60-02-6

Formula: C₂₀H₄₆N₈O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 494.6954

Ref: IN-DA00EAF8

Guanethidine hemisulfate

CAS: 60-02-6

Guanethidine hemisulfate is an experimental drug that inhibits the enzyme activity of guanethidine. It has been shown to have a long-term efficacy in improving cardiac function and reducing diastolic pressure in animals. Guanethidine hemisulfate also has pharmacological properties, including the ability to inhibit the synthesis of protein genes and enzymes, as well as their physiological effects. This drug is used in experimental models of autoimmune diseases and may be useful for treating these conditions.

Formula: C₁₀H₂₂N₄•(H₂O₄S)₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 494.7 g/mol

Ref: 3D-FG23707

Guanethidine Hemisulfate

Controlled Product

CAS: 60-02-6

Stability Hygroscopic
Applications Antihypertensive; antiglaucoma
References Al-Shora, H., et al.: Int. J. Pharm., 47, 209 (1988), Golander, Y., et al.: J. Pharm. Sci., 77, 902 (1988),

Formula: C₁₀H₂₂N₄·H₂O₄S

Color and Shape: Neat

Molecular weight: 494.70

Ref: TR-G815000