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CAS 60-26-4

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Hexamethonium

Description:
Hexamethonium is a quaternary ammonium compound characterized by its structure, which consists of a central nitrogen atom bonded to six carbon atoms, forming a symmetrical arrangement. It is primarily known for its role as a ganglionic blocker, which inhibits the transmission of nerve impulses in the autonomic nervous system. This compound is typically used in research settings and has historical significance in the treatment of hypertension, although its clinical use has diminished due to the development of more effective medications with fewer side effects. Hexamethonium is a white crystalline solid that is soluble in water, and it exhibits a polar nature due to the presence of the quaternary ammonium group. Its mechanism of action involves blocking nicotinic acetylcholine receptors at autonomic ganglia, leading to a decrease in sympathetic and parasympathetic activity. Safety and handling precautions are essential, as it can have significant physiological effects. Overall, hexamethonium serves as an important compound in pharmacological studies and the understanding of autonomic nervous system functions.
Formula:C12H30N2
InChI:InChI=1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2
InChI key:InChIKey=VZJFGSRCJCXDSG-UHFFFAOYSA-N
SMILES:C([N+](C)(C)C)CCCCC[N+](C)(C)C
Synonyms:
  • 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-
  • 1,6-Hexanediaminium, N,N,N,N′,N′,N′-hexamethyl-
  • N1,N1,N1,N6,N6,N6-Hexamethyl-1,6-hexanediaminium
  • Ammonium, hexamethylenebis[trimethyl-
  • Benzohexamethonium
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