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CAS 60-38-8

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Acetylstrophanthidin

Description:
Acetylstrophanthidin, with the CAS number 60-38-8, is a cardiac glycoside derived from the plant Strophanthus, which is known for its use in traditional medicine and its effects on heart function. This compound exhibits a structure characterized by a steroid nucleus with a lactone ring, which is typical of glycosides. Acetylstrophanthidin is recognized for its ability to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular sodium and calcium concentrations, ultimately enhancing cardiac contractility. This mechanism makes it valuable in the treatment of certain heart conditions, such as heart failure and arrhythmias. The compound is typically administered in a controlled manner due to its potent effects and potential toxicity. Its pharmacological profile includes both positive inotropic effects and potential side effects, necessitating careful monitoring in clinical settings. Additionally, acetylstrophanthidin's solubility and stability can vary depending on the formulation and conditions, influencing its therapeutic application.
Formula:C25H34O7
InChI:InChI=1S/C25H34O7/c1-15(27)32-17-3-8-23(14-26)19-4-7-22(2)18(16-11-21(28)31-13-16)6-10-25(22,30)20(19)5-9-24(23,29)12-17/h11,14,17-20,29-30H,3-10,12-13H2,1-2H3/t17-,18+,19-,20+,22+,23-,24-,25-/m0/s1
InChI key:InChIKey=JLZAERUVCODZQO-VWCUIIQSSA-N
SMILES:C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C5=CC(=O)OC5)(CC[C@]1(O)C[C@@H](OC(C)=O)CC2)[H])[H]
Synonyms:
  • (3Beta,5Beta)-3-(Acetyloxy)-5,14-Dihydroxy-19-Oxocard-20(22)-Enolide
  • (3Beta,5Beta,8Xi,9Xi)-3-(Acetyloxy)-5,14-Dihydroxy-19-Oxocard-20(22)-Enolide
  • (3β,5β)-3-(Acetyloxy)-5,14-dihydroxy-19-oxocard-20(22)-enolide
  • 3-(Acetyloxy)-5,14-Dihydroxy-19-Oxocard-20(22)-Enolide
  • 3-Acetyl-strophanthidin
  • 3beta,5,14,19-Tetrahydroxy-5beta-card-20(22)-enolide 19-acetate
  • 5-beta-Card-20(22)-enolide, 19-oxo-3-beta,5,14-trihydroxy-, 3-acetate
  • 5beta,14-Dihydroxy-19-oxocard-20(22)enolide 3beta-acetate
  • 5beta-Card-20(22)-enolide, 3beta,5,14-trihydroxy-19-oxo-, 3-acetate (8CI)
  • 5β-Card-20(22)-enolide, 3β,5,14-trihydroxy-19-oxo-, 3-acetate
  • See more synonyms
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