CAS 60-40-2

Mecamylamine

Description:

Mecamylamine is a chemical compound classified as a tertiary amine, primarily known for its role as a ganglionic blocker. It is often used in pharmacology to manage hypertension and has been investigated for its potential in treating various neurological disorders. The molecular structure of mecamylamine features a piperidine ring, which contributes to its pharmacological activity. It is a white to off-white crystalline solid that is soluble in water and organic solvents. Mecamylamine acts by inhibiting nicotinic acetylcholine receptors, leading to a decrease in sympathetic nervous system activity. This mechanism underlies its therapeutic effects, although it may also result in side effects such as dizziness, dry mouth, and constipation. Due to its ability to cross the blood-brain barrier, mecamylamine has been studied for its effects on cognitive function and addiction. As with any pharmacological agent, careful consideration of dosage and potential interactions with other medications is essential for safe use.

Formula: C₁₁H₂₁N

InChI: InChI=1/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H

InChI key: InChIKey=IMYZQPCYWPFTAG-UHFFFAOYSA-N

SMILES: N(C)C1(C)C2CC(C1(C)C)CC2

Synonyms:

• 2-(Methylamino)-2,3,3-trimethylnorbornane
• 2-(Methylamino)isocamphane
• 2-Norbornanamine, N,2,3,3-tetramethyl-
• 3-(Methylamino)-2,2,3-trimethylbicyclo[2.2.1]heptane
• 3-(Methylamino)isocamphane
• Mecamilamina
• Mecamine
• Mecamylamin
• Mecamylamine
• N,2,3,3-Tetramethyl-2-norbornanamine
• N,2,3,3-Tetramethyl-2-norcamphanamine
• N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine
• N-Methyl-2-isocamphanamine
• Revertina
• methyl(2,3,3-trimethyltrinorbornan-2-yl)amine
• Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-
• N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride (1:1)
• methyl-(2,3,3-trimethylnorbornan-2-yl)amine
• Mekamine
• Mevasine
• methyl(2,3,3-trimethyltrinorbornan-2-yl)amine USP/EP/BP
• Plegangin
• MECAMYLAMINE BASE
• Revetina
• N,5,6,6-tetramethylbicyclo[2.2.1]heptan-5-amine

Mecamylamine

CAS: 60-40-2

Mecamylamine: oral, noncompetitive nAChR blocker, crosses blood-brain barrier, for neuropsychiatric and hypertension research.

Formula: C₁₁H₂₁N

Color and Shape: Solid

Molecular weight: 167.29

Ref: TM-T69019