CAS 60-54-8

(-)-Tetracycline

Description:

(-)-Tetracycline is a broad-spectrum antibiotic belonging to the tetracycline class, characterized by its ability to inhibit bacterial protein synthesis. It is derived from the bacterium Streptomyces aureofaciens and is known for its effectiveness against a wide range of gram-positive and gram-negative bacteria. The chemical structure of (-)-tetracycline features a four-ring system with multiple functional groups, including hydroxyl and dimethylamine groups, which contribute to its solubility and biological activity. This compound exhibits properties such as good oral bioavailability and a relatively long half-life, allowing for effective treatment regimens. (-)-Tetracycline is also known for its potential side effects, including gastrointestinal disturbances and photosensitivity. Additionally, it has been used in various applications beyond human medicine, including veterinary medicine and agriculture, particularly in the treatment of infections and as a growth promoter in livestock. Its mechanism of action primarily involves binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA and inhibiting protein synthesis in bacteria.

Formula: C₂₂H₂₄N₂O₈

InChI: InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChI key: InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N

SMILES: O[C@@]12[C@@](C[C@]3(C(=C1O)C(=O)C=4C([C@@]3(C)O)=CC=CC4O)[H])([C@H](N(C)C)C(O)=C(C(N)=O)C2=O)[H]

Synonyms:

• (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)
• (4S,4aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]-
• 4-(Dimethylamino)-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide
• 6-Methyl-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
• Abramycin
• Achromycin
• Achromycin (naphthacene derivative)
• Acromicina
• Actisite
• Agromicina
• Akne-Pyodron
• Akne-Pyodron Kur
• Ambramicina
• Ambramycin
• Apo-Tetra
• Arcanacycline
• Bio-Tetra
• Biocycline
• Britaciclina
• Calociclina
• Ciclibion
• Cyclomycin
• Cytome
• Deschlorobiomycin
• Dispatetrin
• Economycin
• Enterocycline
• Florocycline
• Gammatet
• Ibicyn
• Kinciclina
• Latycin
• Limecycline
• Medocycline
• Mericycline
• Micycline
• Neocycline
• NorTet
• Novo-Tetra
• Nsc 108579
• Nu-Tetra
• Omegamycin
• Orlycycline
• Panmycin
• Polycycline
• Polycycline (antibiotic)
• Quimocyclin N
• Quimpe Antibiotico
• Resteclin
• Retet
• Robitet Robicaps
• Roviciclina
• Sagittacin N
• Servitet
• Spaciclina
• Steclin V
• Sumycin syrup
• Tetra Hubber
• Tetra-Co
• Tetra-Proter
• Tetrabioptal
• Tetracap
• Tetraciclina
• Tetracitro S
• Tetracyclin
• Tetracycline Base
• Tetracycline Free Base
• Tetradecin
• Tetrafil
• Tetrafosammina
• Tetralan
• Tetralen
• Tetramig
• Tetramykoin
• Tetraseptine
• Triphacycline
• Veracin

Tetracycline Hydrochloride

CAS: 60-54-8, 64-75-5

Formula: C₂₂H₂₄N₂O₈·HCl

Purity: >98.0%(T)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 480.90

Ref: 3B-T2525

Tetracycline

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Purity: >95.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 444.44

Ref: 3B-T3971

Tetracycline

CAS: 60-54-8

Tetracycline, 60-54-8, is a broad-spectrum napthacene antibiotic which inhibits bacterial protein synthesis by binding the 30S ribosomal subunit. Learn more.

Formula: C₂₂H₂₄N₂O₈

Color and Shape: Yellow to orange to brown, Crystalline powder or powder

Molecular weight: 444.44

Ref: 02-J61714

Tetracycline

CAS: 60-54-8

Tetracycline (Tetracyclin) is a broad-spectrum antibiotic. Tetracycline is commonly used in anti-infective studies. Cost-effective and quality-assured.

Formula: C₂₂H₂₄N₂O₈

Purity: 92.65% - 98.18%

Color and Shape: Light Yellow Crystal

Molecular weight: 444.43

Ref: TM-T0912L

(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Purity: 96%

Color and Shape: Solid

Molecular weight: 444.4346

Ref: IN-DA003UNG

Tetracycline, EP grade

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Purity: 88.0 - 102.0 % (dried basis)

Color and Shape: Yellow crystalline powder

Molecular weight: 444.43

Ref: 7W-GA0548

Tetracycline

CAS: 60-54-8

Tetracycline

Purity: ≥80%

Molecular weight: 444.43g/mol

Ref: 54-BUP17381

Tetracycline-13C2-d6 (Oxytetracycline EP Impurity B-13C2-d6)

CAS: 60-54-8

Formula: C₂₀₁₃C₂H₁₈D₆N₂O₈

Molecular weight: 452.46

Ref: 4Z-T-4027

Tetracycline base

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈·xH₂O

Purity: ≥ 91.0%

Color and Shape: Light-yellow to dark yellow powder

Molecular weight: 444.43 (anhydrous)

Ref: 7W-GA9779

Tetracycline 13C22,15N2 dried down 2.5 µg/mL

Controlled Product

CAS: 60-54-8

Formula: C₂₂H₂₄₁₅N₂O₈

Color and Shape: Single Solution

Molecular weight: 468.26

Ref: 04-S17396147DD-2.5

Tetracycline dried down 2.5 µg/mL

Controlled Product

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Color and Shape: Single Solution

Molecular weight: 444.43

Ref: 04-A17396145DD-2.5

Tetracycline (Oxytetracycline EP Impurity B)

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Molecular weight: 444.45

Ref: 4Z-T-4030

Tetracycline

CAS: 60-54-8

Impurity Oxytetracycline Hydrochloride EP Impurity B
Applications Tetracycline is a compound that has been shown to induce apoptosis in various cells. Tetracycline was a useful compound to study drug resistance of pathogens of infections in patients with severe liver disease.
References Yao, L., et al.: Zhongguo Linchuang Yanjiu, 29, 1510 (2016)

Formula: C₂₂H₂₄N₂O₈

Color and Shape: Yellow

Molecular weight: 444.43

Ref: TR-T291413

Tetracycline - Bio-X ™

CAS: 60-54-8

Tetracycline is a broad-spectrum antibiotic that is effective against a variety of bacterial infections. It is a polyketide antibiotic that inhibits protein synthesis by binding to ribosomes and preventing the attachment of amino acids to tRNA molecules thus inhibiting bacterial growth.

Formula: C₂₂H₂₄N₂O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 444.43 g/mol

Ref: 3D-BT166207

Tetracycline

CAS: 60-54-8

Antibiotic of tetracycline class; protein synthesis inhibitor

Formula: C₂₂H₂₄N₂O₈

Purity: Min. 91 Area-%

Color and Shape: Powder

Molecular weight: 444.43 g/mol

Ref: 3D-AT35208

(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-6,10,12,12a-tetrahydroxy-6-methyl-1,3,11-trioxo-1,2,3,4,4a,5,5a,6,11,12a-decahydrotetracene-2-carboxamide

CAS: 60-54-8

Purity: 96%

Molecular weight: 444.4400024

Ref: 10-F862906

Lymecycline EP Impurity H

CAS: 60-54-8

Formula: C₂₂H₂₄N₂O₈

Molecular weight: 444.44

Ref: ST-EA-CP-L64008

Tetracycline-d6

CAS: 60-54-8

Tetracycline-d6 is an antibiotic that inhibits the growth of bacteria by binding to the ribosomal subunit. Tetracycline-d6 is used in the treatment of urinary infections caused by E. coli, Enterobacter cloacae, Klebsiella pneumoniae, and Proteus mirabilis. Tetracycline-d6 has been shown to have antimicrobial activity against a wide range of microorganisms including gram negative and gram positive bacteria, as well as fungi and protozoa. It has been shown to be active against methicillin resistant strains such as S. aureus (MRSA), with an antibacterial efficacy comparable to that of erythromycin. The tetracycline resistance gene is located on plasmids and can be transferred between bacterial cells through conjugation or transduction. Tetracycline-d6 is often used in combination with beta lactam antibiotics such as pen

Purity: Min. 95%

Ref: 3D-FT180092