CAS 60-56-0

Methimazole

Description:

Methimazole is an antithyroid medication primarily used to treat hyperthyroidism, particularly in conditions like Graves' disease. It functions by inhibiting the synthesis of thyroid hormones, specifically by blocking the enzyme thyroid peroxidase, which is crucial for the iodination of tyrosine residues in thyroglobulin. Methimazole is a thiazole derivative, characterized by its molecular formula C4H6N2S, and it typically appears as a white to off-white crystalline powder. It is soluble in water and alcohol, which facilitates its administration in various formulations. The drug is usually taken orally and is known for its relatively rapid onset of action. Common side effects may include rash, gastrointestinal disturbances, and, in rare cases, agranulocytosis, a potentially serious decrease in white blood cell count. Methimazole is contraindicated in pregnancy, particularly during the first trimester, due to potential teratogenic effects. Regular monitoring of thyroid function and blood counts is recommended during treatment to ensure safety and efficacy.

Formula: C₄H₆N₂S

InChI: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChI key: InChIKey=PMRYVIKBURPHAH-UHFFFAOYSA-N

SMILES: S=C1N(C)C=CN1

Synonyms:

• 1,3-Dihydro-1-methyl-2H-imidazole-2-thione
• 1-Methyl-1,3-dihydroimidazole-2-thione
• 1-Methyl-1H-imidazole-2-thiol
• 1-Methyl-2,3-dihydro-1H-imidazole-2-thione
• 1-Methyl-2-mercapto-1H-imidazole
• 1-Methyl-2-mercaptoimidazole
• 1-Methyl-4-imidazoline-2-thione
• 1-Methylimidazole-2(3H)-thione
• 1-Methylimidazole-2-Thiol
• 1-Methylimidazole-2-thione
• 2-Mercapto-1-methyl-1H-imidazole
• 2-Mercapto-N-methylimidazole
• 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-
• 3-Methyl-1H-imidazole-2-thione
• 4-Imidazoline-2-thione, 1-methyl-
• Basolan
• Danantizol
• Favistan
• Frentirox
• Imidazole-2-thiol, 1-methyl-
• MMI
• Mercaptazole
• Mercazole
• Mercazolyl
• Metazolo
• Methiamazole
• Methimazol
• Methimazole
• Methimazole Crystalline
• Methylmercaptoimidazole
• Metizol
• Metothyrin
• Metothyrine
• Metotirin
• N-Methyl-2-mercaptoimidazole
• N-Methylimidazolethiol
• Nsc 38608
• Strumazol
• Tapazole
• Thacapzol
• Thiamazol
• Thiamazole
• Thycapzol
• Thymidazol
• Thymidazole
• Thyrozol

2-Mercapto-1-methylimidazole

CAS: 60-56-0

Formula: C₄H₆N₂S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 114.17

Ref: 3B-M0868

2-Mercapto-1-methylimidazole, 98%

CAS: 60-56-0

Possesses antioxidant properties This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of t

Formula: C₄H₆N₂S

Purity: 98%

Color and Shape: White to cream, Crystals or powder or crystalline powder

Molecular weight: 114.17

Ref: 02-A13094

THIAMAZOLE CRS

CAS: 60-56-0

THIAMAZOLE CRS

Ref: 41-Y0000336

Methimazole

CAS: 60-56-0

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure nesoi

Formula: C₄H₆N₂S

Color and Shape: White Powder

Molecular weight: 114.17

Ref: 45-1411005

2H-​Imidazole-​2-​thione, 1,​3-​dihydro-​1-​methyl-

CAS: 60-56-0

Formula: C₄H₆N₂S

Purity: 97%

Color and Shape: Solid

Molecular weight: 114.1688

Ref: IN-DA00IAN2

Methimazole

CAS: 60-56-0

Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.

Formula: C₄H₆N₂S

Purity: 99.21% - 99.59%

Color and Shape: White Solid

Molecular weight: 114.17

Ref: TM-T0840

1,3-Dihydro-1-methyl-2H-imidazole-2-thione

CAS: 60-56-0

1,3-Dihydro-1-methyl-2H-imidazole-2-thione

Formula: C₄H₆N₂S

Purity: 99%

Color and Shape: off white crystalline powder

Molecular weight: 114.17g/mol

Ref: 54-OR28714

Methimazole

CAS: 60-56-0

Methimazole

Purity: ≥98%

Molecular weight: 114.17g/mol

Ref: 54-BUP18869

Methimazole

CAS: 60-56-0

Formula: C₄H₆N₂S

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White, off-white or pale yellow crystalline powder

Molecular weight: 114.17

Ref: 7W-GP2312

Thiamazole (Methimazole)

CAS: 60-56-0

Formula: C₄H₆N₂S

Molecular weight: 114.17

Ref: 4Z-T-416006

Methimazole, USP grade

CAS: 60-56-0

Formula: C₄H₆N₂S

Purity: 98.0 - 101.0 % (dry basis)

Color and Shape: White to off-white powder

Molecular weight: 114.17

Ref: 7W-GP4973

Methimazol 100 µg/mL in Acetonitrile

CAS: 60-56-0

Formula: C₄H₆N₂S

Color and Shape: Single Solution

Molecular weight: 114.17

Ref: 04-V15020200AL-100

Thiamazole

Controlled Product

CAS: 60-56-0

Formula: C₄H₆N₂S

Color and Shape: Neat

Molecular weight: 114.17

Ref: 86-MM0889.00

Methimazol

Controlled Product

CAS: 60-56-0

Formula: C₄H₆N₂S

Color and Shape: Neat

Molecular weight: 114.17

Ref: 04-C15020200

Methimazole

CAS: 60-56-0

Applications Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),

Formula: C₄H₆N₂S

Color and Shape: Light Brown

Molecular weight: 114.17

Ref: TR-M260300

1-Methyl-1H-imidazole-2(3H)-thione

CAS: 60-56-0

Formula: C₄H₆N₂S

Purity: 95%

Molecular weight: 114.17

Ref: 10-F322149

2-Mercapto-1-methylimidazole

CAS: 60-56-0

Inhibitor of thyroid peroxidase; treatment for hyperthyroidism

Formula: C₄H₆N₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 114.17 g/mol

Ref: 3D-FM25155