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CAS 60-56-0

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Methimazole

Description:
Methimazole is an antithyroid medication primarily used to treat hyperthyroidism, particularly in conditions like Graves' disease. It functions by inhibiting the synthesis of thyroid hormones, specifically by blocking the enzyme thyroid peroxidase, which is crucial for the iodination of tyrosine residues in thyroglobulin. Methimazole is a thiazole derivative, characterized by its molecular formula C4H6N2S, and it typically appears as a white to off-white crystalline powder. It is soluble in water and alcohol, which facilitates its administration in various formulations. The drug is usually taken orally and is known for its relatively rapid onset of action. Common side effects may include rash, gastrointestinal disturbances, and, in rare cases, agranulocytosis, a potentially serious decrease in white blood cell count. Methimazole is contraindicated in pregnancy, particularly during the first trimester, due to potential teratogenic effects. Regular monitoring of thyroid function and blood counts is recommended during treatment to ensure safety and efficacy.
Formula:C4H6N2S
InChI:InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChI key:InChIKey=PMRYVIKBURPHAH-UHFFFAOYSA-N
SMILES:S=C1N(C)C=CN1
Synonyms:
  • 1,3-Dihydro-1-methyl-2H-imidazole-2-thione
  • 1-Methyl-1,3-dihydroimidazole-2-thione
  • 1-Methyl-1H-imidazole-2-thiol
  • 1-Methyl-2,3-dihydro-1H-imidazole-2-thione
  • 1-Methyl-2-mercapto-1H-imidazole
  • 1-Methyl-2-mercaptoimidazole
  • 1-Methyl-4-imidazoline-2-thione
  • 1-Methylimidazole-2(3H)-thione
  • 1-Methylimidazole-2-Thiol
  • 1-Methylimidazole-2-thione
  • See more synonyms
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