CAS 60-81-1

Phloridzin

Description:

Phloridzin, with the CAS number 60-81-1, is a naturally occurring flavonoid glycoside primarily found in the bark of apple trees and other plants. It is characterized by its chemical structure, which consists of a phloretin backbone linked to a glucose molecule. Phloridzin exhibits several notable biological properties, including antioxidant, anti-inflammatory, and potential anti-diabetic effects, as it can inhibit glucose reabsorption in the kidneys. This compound is also known for its role in plant defense mechanisms and has been studied for its potential health benefits in humans, particularly in relation to metabolic disorders. In terms of physical properties, phloridzin is typically a white to pale yellow crystalline powder, soluble in water and organic solvents. Its stability can be influenced by factors such as pH and temperature. Due to its diverse biological activities, phloridzin has garnered interest in both pharmacological research and the food industry, particularly in the context of functional foods and dietary supplements.

Formula: C₂₁H₂₄O₁₀

InChI: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1

InChI key: InChIKey=IOUVKUPGCMBWBT-QNDFHXLGSA-N

SMILES: C(CCC1=CC=C(O)C=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2O

Synonyms:

• 1-Propanone, 1-[2-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
• 1-[2-(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
• 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
• 2'-(β-D-Glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenon
• 2'-(β-D-glucopiranosiloxi)-4',6'-dihidroxi-3-(4-hidroxifenil)propiofenona
• 2'-(β-D-glucopyrannosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
• 2'-(β-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
• Dihydrochalcone 2′-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Floridzin
• Nsc 2833
• Phloretin 2'-O-glucoside
• Phloretin 2'-glucoside
• Phloretin 2′-O-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Phloretin 2′-β-<span class="text-smallcaps">D</span>-Glucoside
• Phloretin glucoside
• Phlorhizin
• Phloridzin
• Phloridzosid
• Phlorizin
• Phlorizine
• Phlorizoside
• Phlorrhizin
• 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
• 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl β-D-glucopyranoside
• 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl hexopyranoside
• Phlorizin dihydrate

Phlorizin

CAS: 60-81-1, 7061-54-3

Formula: C₂₁H₂₄O₁₀

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 436.41

Ref: 3B-P0248

Phloridzin

CAS: 60-81-1

Phloridzin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₁H₂₄O₁₀

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 436.42

Ref: 11-1361S

Phlorizin

CAS: 60-81-1

Phlorizin

Purity: 98%

Molecular weight: 436.41g/mol

Ref: 54-OR1029277

Phlorizin

CAS: 60-81-1

Phlorizin

Purity: ≥98%

Molecular weight: 436.41g/mol

Ref: 54-BUP18505

Phlorizin

CAS: 60-81-1

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 436.4129943847656

Ref: 10-F079095

Phloridzin

CAS: 60-81-1

Formula: C₂₁H₂₄O₁₀

Purity: 95%~99%

Molecular weight: 436.413

Ref: BP-BP1089

Phlorizin

CAS: 60-81-1

Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .

Formula: C₂₁H₂₄O₁₀

Purity: 99.73% - 99.77%

Color and Shape: Solid Crystalline

Molecular weight: 436.41

Ref: TM-T2922

Phloridzin

CAS: 60-81-1

Formula: C₂₁H₂₄O₁₀

Purity: ≥ 98.0%

Color and Shape: Off-white to light yellow powder

Molecular weight: 436.41

Ref: 7W-GC6883

Phloridzin

CAS: 60-81-1

Natural glycoside

Formula: C₂₁H₂₄O₁₀

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 436.42

Ref: 5G-80513

Phloridzin

Controlled Product

CAS: 60-81-1

Applications It is a dihydrochalcone occurring in all parts of the apple tree except the mature fruit. Once thought to occur in pear, plum, cherry trees and other Rosaceae. Inhibitor of Na+-glucose cotransporters (SGLT). inhibits both SGLT1 and SGLT2 with low therapeutic selectivity. Cytotoxic to Breast Cancer cells with potent antioxidant and antibacterial activity. Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
References Moelwyn-Hughes EA, 1930. J Gen Physiol. Jul 20;13(6):807-17.Chang-Ik, 2016. Molecules, 21, 1136Fernando W, et al. 2016. Carcinogenesis. 2016 Oct;37(10):1004-13

Formula: C₂₁H₂₄O₁₀

Color and Shape: Neat

Molecular weight: 436.41

Ref: TR-P339500

Phloridzin

CAS: 60-81-1

Phloridzin is a flavonoid glycoside, which is primarily sourced from apple trees and other members of the Rosaceae family. It is naturally found in the bark, roots, and other parts of the plant. The mode of action of phloridzin involves its function as an inhibitor of the sodium-glucose transporters (SGLT1 and SGLT2). By blocking these transporters, phloridzin prevents the reabsorption of glucose in the renal tubules, thus promoting the excretion of glucose through urine.

Formula: C₂₁H₂₄O₁₀

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 436.41 g/mol

Ref: 3D-MP08132