CAS 60-82-2

Phloretin

Description:

Phloretin is a naturally occurring dihydrochalcone, primarily found in the bark of apple trees and other plants. It is characterized by its chemical formula C15H14O5 and a molecular weight of approximately 270.3 g/mol. Phloretin exhibits a yellowish crystalline appearance and is soluble in organic solvents such as ethanol and dimethyl sulfoxide, but has limited solubility in water. This compound is known for its antioxidant properties and potential health benefits, including anti-inflammatory and anti-cancer effects. Phloretin has garnered attention in the field of skincare for its ability to enhance skin penetration of other compounds and its role in protecting skin cells from oxidative stress. Additionally, it has been studied for its potential to inhibit certain enzymes, such as glucose transporters, which may have implications for diabetes management. Overall, phloretin is a versatile compound with applications in both the food and pharmaceutical industries, as well as in cosmetic formulations.

Formula: C₁₅H₁₄O₅

InChI: InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

InChI key: InChIKey=VGEREEWJJVICBM-UHFFFAOYSA-N

SMILES: C(CCC1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O

Synonyms:

• 1-(2,6-Dihydroxy-4-Methoxyphenyl)Ethanone
• 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
• 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)Propiophenone
• 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone
• 2′,4′,6′-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone
• 2′,4′,6′-Trihydroxy-3-(p-hydroxyphenyl)propiophenone
• 3-(4-Hidroxifenil)-1-(2,4,6-Trihidroxifenil)Propan-1-Ona
• 3-(4-Hydroxyphenyl)-1-(2,4,6-Trihydroxyphenyl)Propan-1-One
• 3-(4-Hydroxyphenyl)-1-(2,4,6-Trihydroxyphenyl)Propane-1-One
• 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
• 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on
• Dihydronaringenin
• Floretin
• Naringenin dihydrochalcone
• Nsc 407292
• Phloretol
• Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-
• Propiophenone, 2′,4′,6′-trihydroxy-3-(p-hydroxyphenyl)-
• Rjc 02792
• α,β-Dihydrochalconaringenin
• β-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
• β-(p-Hydroxyphenyl)phloropropiophenone

Phloretin

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 274.27

Ref: 3B-P1966

Phloretin, 98%

CAS: 60-82-2

Topical antioxidant This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand tran

Formula: C₁₅H₁₄O₅

Purity: 98%

Color and Shape: Cream or pale pink, Crystals or powder or crystalline powder

Molecular weight: 274.27

Ref: 02-L10991

Phloretin

CAS: 60-82-2

Phloretin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₁₅H₁₄O₅

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 274.27

Ref: 11-1360S

Phloretin

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 274.2687

Ref: IN-DA003TQP

Phloretin

CAS: 60-82-2

Phloretin

Purity: ≥98%

Molecular weight: 274.27g/mol

Ref: 54-BUP18014

Phloretin

CAS: 60-82-2

Phloretin

Purity: 98%

Molecular weight: 274.27g/mol

Ref: 54-OR1014661

Phloretin

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: Off-white to light-pink powder

Molecular weight: 274.28

Ref: 7W-GE3120

Phloretin

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Color and Shape: Light Pink To Off-White Solid

Molecular weight: 274.27

Ref: 4Z-P-271001

Phloretin

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Purity: 95%~99%

Molecular weight: 274.272

Ref: BP-BP1088

Phloretin

CAS: 60-82-2

Phloretin (NSC-407292) inhibits eukaryotic urea transporters, has antioxidative properties, and can induce cancer cell apoptosis. Found in apples and apricots.

Formula: C₁₅H₁₄O₅

Purity: 98.53% - >99.99%

Color and Shape: Solid

Molecular weight: 274.27

Ref: TM-T2924

Phloretin

CAS: 60-82-2

Ketone phenol

Formula: C₁₅H₁₄O₅

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 274.27

Ref: 5G-82624

Phloretin

Controlled Product

CAS: 60-82-2

Applications The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.
References Constantinescu, S.N., et al.: FEBS Lett., 292, 31 (1991), Mann, J., et al.: Appl. Physiol., 71, 410 (1991), Benga, G., et al.: Eur. J. Cell Biol., 59, 219 (1992), Kitanaka, J., et al.: J. Neurochem., 60, 704 (1993), Wang, X., et al.: Biochem. J., 290, 249 (1993)

Formula: C₁₅H₁₄O₅

Color and Shape: Off White Solid

Molecular weight: 274.27

Ref: TR-P339000

Phloretin

CAS: 60-82-2

Phloretin is a dihydrochalcone, which is a type of polyphenol, derived primarily from apple tree leaves and the bark of certain fruit trees. It exhibits its biological activity through its ability to disrupt various cellular processes, including inhibiting specific enzyme activities and interfering with the transport of glucose across cell membranes. This is primarily due to its ability to penetrate cellular lipid bilayers, allowing it to interact with intracellular molecules effectively.

Formula: C₁₅H₁₄O₅

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 274.27 g/mol

Ref: 3D-FP06961

2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone

CAS: 60-82-2

Formula: C₁₅H₁₄O₅

Purity: 98%

Color and Shape: White powder

Molecular weight: 274.272

Ref: 10-F002612