CAS 600-99-7

(11beta)-11,17,21-trihydroxypregna-4,6-diene-3,20-dione

Description:

The chemical substance known as (11beta)-11,17,21-trihydroxypregna-4,6-diene-3,20-dione, with the CAS number 600-99-7, is commonly referred to as hydrocortisone or cortisol. It is a steroid hormone produced by the adrenal cortex and plays a crucial role in various physiological processes, including metabolism, immune response regulation, and stress response. Hydrocortisone is characterized by its three hydroxyl (-OH) groups and a ketone group, which contribute to its biological activity. It exhibits anti-inflammatory and immunosuppressive properties, making it significant in medical treatments for conditions such as allergies, asthma, and autoimmune diseases. The compound is typically administered in various forms, including topical creams, oral tablets, and injectable solutions. Hydrocortisone's structure allows it to bind to glucocorticoid receptors, influencing gene expression and cellular functions. Additionally, it is involved in the regulation of glucose metabolism and has effects on electrolyte balance. Its therapeutic use must be carefully managed due to potential side effects associated with prolonged exposure.

Formula: C₂₁H₂₈O₅

InChI: InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h3-4,9,14-16,18,22,24,26H,5-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

Synonyms:

• 11β,17,21-Trihydroxypregna-4,6-diene-3,20-dione
• Hydrocortisone impurity E (EP)
• Hydrocortisone EP Impurity E
• Delta6-Hydrocortisone
• Hydrocortisone Impurity 5（Hydrocortisone EP Impurity E）
• Hydrocortisone EP Impurity E (6-Hydrocortisone/ 6-Dehydrocortisol)
• 6-Dehydrocortisol
• Pregna-4,6-diene-3,20-dione, 11,17,21-trihydroxy-, (11β)- (9CI)
• Hydrocortisone EP IMP E

6-Dehydro Cortisol (11β,17,21-Trihydroxypregna-4,6-diene-3,20-dione)

CAS: 600-99-7

Ketone-alcohols and ketone-aldehydes, nesoi

Formula: C₂₁H₂₈O₅

Color and Shape: Off-White Powder

Molecular weight: 360.19367

Ref: 45-1A11640

Hydrocortisone EP Impurity E (δ-6-Hydrocortisone)

CAS: 600-99-7

Formula: C₂₁H₂₈O₅

Molecular weight: 360.45

Ref: 4Z-H-103030

11β,17,21-Trihydroxypregna-4,6-diene-3,20-dione (Δ6-Hydrocortisone)

Controlled Product

CAS: 600-99-7

Formula: C₂₁H₂₈O₅

Color and Shape: Light Yellow

Molecular weight: 360.44

Ref: 86-MM0185.07

Hydrocortisone EP Impurity E

CAS: 600-99-7

Formula: C₂₁H₂₈O₅

Molecular weight: 360.5

Ref: ST-EA-CP-H9005

6-Dehydrocortisol

Controlled Product

CAS: 600-99-7

Impurity Hydrocortisone EP Impurity E
Applications 6-Dehydrocortisol (Hydrocortisone EP Impurity E) is a metabolite of Cortisol (H714615), a glucocorticoid, produced by the zona fasciculata of the adrenal gland. 6-Dehydrocortisol was used in the identification of Trp-371 as the main site of specific photoaffinity labeling of corticosteroid binding globulin.
References Grenot, C., et al.: Biochem., 33, 8969 (1994); Justice, J.B., et al.: J. Med. Chem., 21, 465 (1978); Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Formula: C₂₁H₂₈O₅

Color and Shape: Light Yellow

Molecular weight: 360.44

Ref: TR-D229145

6-Dehydrocortisol-d4

Controlled Product

CAS: 600-99-7

Formula: C₂₁D₄H₂₄O₅

Color and Shape: Neat

Molecular weight: 364.469

Ref: TR-D229147

6-Dehydrocortisol

Controlled Product

CAS: 600-99-7

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Formula: C₂₁H₂₈O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 360.44 g/mol

Ref: 3D-AAA60099