CAS 6000-74-4

Hydrocortisone sodium phosphate

Description:

Hydrocortisone sodium phosphate, with the CAS number 6000-74-4, is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is a sodium salt of hydrocortisone, which enhances its solubility in water, making it suitable for parenteral administration. This compound appears as a white to off-white crystalline powder and is hygroscopic, meaning it can absorb moisture from the air. Hydrocortisone sodium phosphate is often utilized in the treatment of various conditions, including allergies, skin disorders, and adrenal insufficiency. Its mechanism of action involves the modulation of gene expression, leading to reduced inflammation and immune response. The substance is typically administered via injection or as part of topical formulations. Stability is a key characteristic, as it can degrade under certain conditions, necessitating proper storage and handling. Overall, hydrocortisone sodium phosphate is an important therapeutic agent in clinical practice, particularly in managing acute and chronic inflammatory conditions.

Formula: C₂₁H₃₁O₈P·2Na

InChI: InChI=1S/C21H31O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h9,14-16,18,23,25H,3-8,10-11H2,1-2H3,(H2,26,27,28);;/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1

InChI key: InChIKey=KKFIZYONMZSRGA-OJJGEMKLSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COP(=O)(O)O)=O)O)[H].[Na]

Synonyms:

• Cleiton
• Cortisol 21-phosphate disodium salt
• Cortisol sodium phosphate
• Cortisol, 21-(dihydrogen phosphate), disodium salt
• Disodium (11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Phosphate
• Disodium (8Xi,9Xi,10Xi,13Xi,14Xi)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Phosphate
• Disodium hydrocortisone 21-phosphate
• Efcortesol
• Hydrocortisone 21-disodium phosphate
• Hydrocortisone 21-disodium salt
• Hydrocortisone 21-phosphate disodium
• Hydrocortisone 21-phosphate disodium salt
• Hydrocortisone 21-sodium phosphate
• Hydrocortisone Sodium Phosphate
• Hydrocortisone disodium phosphate
• Hydrocortone phosphate
• Physiocortison
• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-
• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt (1:2), (11β)-
• Sodium cortisol 21-phosphate

Hydrocortisone sodium phosphate

CAS: 6000-74-4

Hydrocortisone sodium phosphate

Color and Shape: Off-White

Ref: 47-188

Hydrocortisone phosphate (sodium)

CAS: 6000-74-4

Formula: C₂₁H₂₉Na₂O₈P

Purity: 98%

Color and Shape: Solid

Molecular weight: 486.4035

Ref: IN-DA00E9AW

Hydrocortisone Phosphate Disodium Salt

CAS: 6000-74-4

Formula: C₂₁H₂₉O₈P·2Na

Molecular weight: 440.43 2*22.99

Ref: 4Z-H-103066

Hydrocortisone Sodium Phosphate RS

CAS: 6000-74-4

Color and Shape: White To Light Yellow Solid Powder

Ref: 2K-1123000021

Hydrocortisone Sodium Phosphate

CAS: 6000-74-4

Stability Hygroscopic
Applications Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).
References Torre Noceda, V. et al.: Cien. Indust. Farm., 5, 203 (1973);

Formula: C₂₁H₂₉O₈P·2Na

Color and Shape: White To Off-White

Molecular weight: 486.40

Ref: TR-H714690

Hydrocortisone sodium phosphate

CAS: 6000-74-4

Hydrocortisone sodium phosphate is a potent anti-inflammatory agent that belongs to a class of drugs called corticosteroids. It is used to treat inflammatory bowel disease, rheumatoid arthritis, and other autoimmune diseases. Hydrocortisone sodium phosphate inhibits the production of cytokines and mediators of inflammation by inhibiting the activity of leukocytes such as human polymorphonuclear leukocytes (PMN) and lymphocytes. Hydrocortisone sodium phosphate also has antimicrobial effects against bacteria that are sensitive to this drug. This agent is metabolized in vivo to hydrocortisone by esterases, which are found in the kidney, liver, or gut wall. Hydrocortisone sodium phosphate can inhibit drug metabolism by cytochrome P450 enzymes (CYP3A4).

Formula: C₂₁H₂₉Na₂O₈P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 486.4 g/mol

Ref: 3D-FH36999

Hydrocortisone phosphate sodium

CAS: 6000-74-4

Hydrocortisone phosphate sodium: a mild, short-acting steroid for studying eye diseases and gastric ulcers.

Formula: C₂₁H₂₉Na₂O₈P

Color and Shape: Solid

Molecular weight: 486.408

Ref: TM-T63227

Hydrocortisone Sodium Phosphate

CAS: 6000-74-4

Formula: C₂₁H₂₉O₈P₂(Na)

Molecular weight: 440.4 : 2(23.0)

Ref: ST-EA-CP-H9085