CAS 60084-10-8

Tiazofurin

Description:

Tiazofurin, with the CAS number 60084-10-8, is a synthetic nucleoside analog that exhibits antiviral properties, particularly against certain RNA viruses. It is characterized by its unique structure, which includes a thiazole ring fused to a ribofuranosyl moiety. This compound functions primarily by inhibiting viral replication, making it of interest in the treatment of viral infections. Tiazofurin is known to interfere with the synthesis of nucleic acids, thereby disrupting the viral life cycle. In addition to its antiviral activity, it has been studied for potential applications in cancer therapy due to its ability to affect cellular metabolism and proliferation. The compound is typically administered in a pharmaceutical formulation, and its efficacy and safety profile have been evaluated in various clinical studies. However, like many nucleoside analogs, it may also exhibit side effects, which necessitate careful monitoring during treatment. Overall, Tiazofurin represents a significant area of research in both virology and oncology.

Formula: C₉H₁₂N₂O₅S

InChI: InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1

InChI key: InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NC(C(N)=O)=CS2

Synonyms:

• (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
• 1,4-Anhydro-1-(4-Carbamoyl-1,3-Thiazol-2-Yl)Pentitol
• 2-beta-D-Ribofuranosyl-4-thiazolecarboxamide
• 2-beta-D-Ribofuranosylthiazole-4-carboxamide
• 2-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-4-thiazolecarboxamide
• 2-β-<span class="text-smallcaps">D</span>-Ribofuranosylthiazole-4-carboxamide
• 4-Thiazolecarboxamide, 2-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• Ci 909
• NSC 286-193
• NSC 286193
• Riboxamide
• Tiazofurine
• 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl-
• 2-β-D-Ribofuranosyl-4-thiazolecarboxamide
• 2-β-D-Ribofuranosylthiazole-4-carboxamide

2-b-D-Ribofuranosyl-4-thiazolecarboxamide

CAS: 60084-10-8

Formula: C₉H₁₂N₂O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 260.2670

Ref: IN-DA00ECLY

Tiazofurin

CAS: 60084-10-8

Tiazofurin

Purity: ≥98%

Molecular weight: 260.27g/mol

Ref: 54-BUP09282

Tiazofurin

CAS: 60084-10-8

Ref: 7W-GC0046

Tiazofurin

CAS: 60084-10-8

Tiazofurin, a synthetic nucleoside, has anti-cancer effects and inhibits IMPDH as TAD after metabolism.

Formula: C₉H₁₂N₂O₅S

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 260.27

Ref: TM-T40686

Tiazofurin

Controlled Product

CAS: 60084-10-8

Stability Very Very Hygroscopic
Applications Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.
References Streeter, D.G. et al.: Biochem. Biophys. Res. Comm., 115, 544 (1983); Boritzki, T. et al.: Biochem. Pharmacol., 34, 1109 (1985); Malek, K. et al.: Leuk. Res., 28, 1125 (2004);

Formula: C₉H₁₂N₂O₅S

Color and Shape: Neat

Molecular weight: 260.27

Ref: TR-T437200

Tiazofurin

CAS: 60084-10-8

Tiazofurin is a novel anticancer agent that inhibits the activity of various enzymes, including dehydrogenase and acetyl-CoA carboxylase. Tiazofurin shows significant cytotoxicity against human leukemia cells in vitro. It also has an anti-infectious effect on hl-60 cells and k562 cells, which are carcinoma cell lines. Tiazofurin has been shown to have a higher inhibitory effect on dextran sulfate than on basic protein in vitro, suggesting that it may be more effective as an anticancer compound against cancerous tumors with high levels of glycolipids.

Formula: C₉H₁₂N₂O₅S

Purity: Min. 95%

Color and Shape: Off-White Slightly Brown Powder

Molecular weight: 260.27 g/mol

Ref: 3D-MT16870

Tiazofurin

CAS: 60084-10-8

Purity: 98%

Molecular weight: 260.2600098

Ref: 10-F603507