CAS 60113-83-9

Valproic acid glucuronide

Description:

Valproic acid glucuronide is a metabolite of valproic acid, a medication primarily used to treat epilepsy and bipolar disorder. This compound is formed through the process of glucuronidation, where a glucuronic acid moiety is conjugated to valproic acid, enhancing its solubility and facilitating excretion. Valproic acid glucuronide is characterized by its relatively high polarity compared to its parent compound, which affects its pharmacokinetics and bioavailability. It is typically found in biological fluids, such as urine, where it serves as a marker for valproic acid metabolism. The compound is generally considered to be less pharmacologically active than valproic acid itself, but its presence is important for understanding the drug's metabolic pathways and potential interactions. Additionally, the study of valproic acid glucuronide can provide insights into individual variations in drug metabolism, which can influence therapeutic outcomes and side effects in patients undergoing treatment with valproic acid.

Formula: C₁₄H₂₄O₈

InChI: InChI=1S/C14H24O8/c1-3-5-7(6-4-2)13(20)22-14-10(17)8(15)9(16)11(21-14)12(18)19/h7-11,14-17H,3-6H2,1-2H3,(H,18,19)/t8-,9-,10+,11-,14-/m0/s1

InChI key: InChIKey=XXKSYIHWRBBHIC-JVWRJRKNSA-N

SMILES: O(C(C(CCC)CCC)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O

Synonyms:

• 1-(2-propylpentanoate) beta-D-Glucopyranuronic acid
• 1-O-Valproyl-β-<span class="text-smallcaps">D</span>-glucopyranuronic acid
• Dipropylacetate glucuronide
• Valproate glucuronide
• Valproate-β-<span class="text-smallcaps">D</span>-glucuronide
• Valproic acid glucuronide
• Vpa-G
• β-<span class="text-smallcaps">D</span>-Glucopyranuronic acid, 1-(2-propylpentanoate)
• β-D-Glucopyranuronic acid, 1-(2-propylpentanoate)

Valproic acid-acyl-D-glucuronide

CAS: 60113-83-9

Valproic acid-acyl-D-glucuronide

Purity: >98%

Color and Shape: White Lyophilised Powder

Molecular weight: 320.34g/mol

Ref: 54-BICL4186

Valproic acid-acyl-β-D-glucuronide

CAS: 60113-83-9

Formula: C₁₄H₂₄O₈

Molecular weight: 320.34

Ref: 4Z-V-063

Valproic acid b-D-glucuronide

CAS: 60113-83-9

Formula: C₁₄H₂₄O₈

Purity: ≥ 95.0%

Color and Shape: White to beige or yellow powder

Molecular weight: 320.34

Ref: 7W-GC0999

Valproic Acid-d6 β-D-Glucuronide

Controlled Product

CAS: 60113-83-9

Stability Hygroscopic
Applications A labelled metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Formula: C₁₄H₁₈D₆O₈

Color and Shape: Neat

Molecular weight: 326.37

Ref: TR-V094762

Valproic Acid β-D-Glucuronide

Controlled Product

CAS: 60113-83-9

Stability Hygroscopic
Applications A metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Formula: C₁₄H₂₄O₈

Color and Shape: Off-White

Molecular weight: 320.34

Ref: TR-V094760

Valproic Acid-d15 β-D-Glucuronide

Controlled Product

CAS: 60113-83-9

Applications Valproic Acid-d15 β-D-Glucuronide, is the labeled analogue of Valproic Acid β-D-Glucuronide (V094760), a metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Formula: C₁₄H₉D₁₅O₈

Color and Shape: Neat

Molecular weight: 335.43

Ref: TR-V094763

Valproic acid b-D-glucuronide

Controlled Product

CAS: 60113-83-9

Valproic acid b-D-glucuronide is a drug that belongs to the group of anticonvulsants. Valproic acid b-D-glucuronide inhibits the activity of glutamate, which is an excitatory neurotransmitter in the brain. It also causes irreversible inhibition of GluCl channels and increases diastolic pressure. Valproic acid b-D-glucuronide has been shown to have anti-inflammatory properties, as it reduces the production of prostaglandins and cytokines. The drug has been used in animal models to study pain perception and chronic pain syndromes such as bone cancer or metabolic disorders. Valproic acid b-D-glucuronide also blocks GABA receptors, causing increased levels of gamma aminobutyric acid (GABA) and dopamine. The drug has been shown to induce a state of deep sleep in rats that are deprived from REM sleep for three weeks.

Formula: C₁₄H₂₄O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 320.34 g/mol

Ref: 3D-MV16889

Valproic Acid b-D-Glucuronide

CAS: 60113-83-9

Formula: C₁₄H₂₄O₈

Molecular weight: 320.34

Ref: ST-EA-CP-V6023