CAS 60129-59-1

7-Deaza-2′-deoxyadenosine

Description:

7-Deaza-2′-deoxyadenosine is a modified nucleoside that serves as an analog of adenosine, where the nitrogen atom at the 7-position of the purine ring is replaced by a carbon atom. This structural modification imparts unique properties to the molecule, influencing its biological activity and stability. The compound is characterized by its ability to participate in nucleic acid synthesis and is often utilized in biochemical research and pharmaceutical applications, particularly in the study of nucleic acid interactions and enzyme mechanisms. It exhibits a similar base-pairing ability to adenosine, making it a valuable tool in the development of nucleoside analogs for therapeutic purposes. Additionally, 7-Deaza-2′-deoxyadenosine can affect the binding affinity of nucleic acids to proteins, potentially altering gene expression and cellular processes. Its solubility and stability in various solvents make it suitable for laboratory use, while its unique properties may lead to applications in antiviral and anticancer drug development. Overall, this compound represents an important area of study in medicinal chemistry and molecular biology.

Formula: C₁₁H₁₄N₄O₃

InChI: InChI=1S/C11H14N4O3/c12-10-6-1-2-15(11(6)14-5-13-10)9-3-7(17)8(4-16)18-9/h1-2,5,7-9,16-17H,3-4H2,(H2,12,13,14)/t7-,8+,9+/m0/s1

InChI key: InChIKey=NIJSNUNKSPLDTO-DJLDLDEBSA-N

SMILES: NC1=C2C(N(C=C2)[C@@H]3O[C@H](CO)[C@@H](O)C3)=NC=N1

Synonyms:

• (2R,3S,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
• 2′-Deoxy-7-deazaadenosine
• 2′-Deoxytubercidin
• 2′-Deoxyxylotubercidin
• 7-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7-Deaza-2'-deoxyadenosine
• 7-Deaza-deoxyadenosine
• 7-Deazadeoxyadenosine
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-
• 7H-Pyrrolo[2,3-d]pyrimidine, 4-amino-7-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-
• Deoxytubercidin
• 7H-Pyrrolo[2,3-d]pyrimidine, 4-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-
• 7-(2-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-Deaza-2'-dA

CAS: 60129-59-1

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 250.258

Ref: 10-F463455

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-(2-deoxy-b-D-erythro-pentofuranosyl)-

CAS: 60129-59-1

Formula: C₁₁H₁₄N₄O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 250.2539

Ref: IN-DA003NF2

7-Deaza-2''-deoxyadenosine

CAS: 60129-59-1

Formula: C₁₁H₁₄N₄O₃

Purity: ≥ 98.0% (HPLC)

Color and Shape: White to off-white crystalline powder

Molecular weight: 250.25

Ref: 7W-GN9637

(2R,3S,5R)-5-(4-Amino-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol

CAS: 60129-59-1

(2R,3S,5R)-5-(4-Amino-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol

Purity: 98%

Molecular weight: 250.25g/mol

Ref: 54-OR1007992

7-Deaza-2'-deoxyadenosine

CAS: 60129-59-1

Nucleoside Derivatives –7-Deaza-purine nucleosides; Drugs and Inhibitors; Purine nucleoside phosphorylase inhibitor

Formula: C₁₁H₁₄N₄O₃

Color and Shape: Solid

Molecular weight: 250.25

Ref: TM-TNU1023

(2R,3S,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

CAS: 60129-59-1

Purity: 97%

Molecular weight: 250.25799560546875

Ref: 10-F616730

7-Deaza-2'-deoxyadenosine

CAS: 60129-59-1

7-Deaza-2'-deoxyadenosine is an oligodeoxynucleotide analog that has been shown to be a potent inhibitor of human ovarian carcinoma cells. It inhibits the uptake of organic anion transporters, which are proteins found in the cell membrane that transport organic anions such as nucleosides and nucleotides. 7-Deaza-2'-deoxyadenosine has also been shown to inhibit DNA synthesis and polymerase chain reactions by binding to the enzyme RNA polymerase II. This drug can be synthesized with solid phase chemistry, making it a highly reproducible product.

Formula: C₁₁H₁₄N₄O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 250.26 g/mol

Ref: 3D-ND02936