CAS 60136-25-6

5-Isopropyl-2′-deoxyuridine

Description:

5-Isopropyl-2′-deoxyuridine is a nucleoside analog that features a modified uridine structure, where an isopropyl group is attached to the 5-position of the pyrimidine ring. This compound is characterized by its ability to mimic natural nucleosides, which makes it of interest in biochemical and pharmaceutical research, particularly in the study of nucleic acid metabolism and antiviral therapies. The presence of the isopropyl group can influence the compound's solubility, stability, and interaction with nucleic acid polymerases. As a deoxyuridine derivative, it lacks the hydroxyl group at the 2′ position, which is significant for its biological activity and incorporation into DNA. The CAS number 60136-25-6 uniquely identifies this compound in chemical databases, facilitating its study and application in various scientific fields. Overall, 5-Isopropyl-2′-deoxyuridine serves as a valuable tool in understanding nucleoside function and developing therapeutic agents.

Formula: C₁₂H₁₈N₂O₅

InChI: InChI=1/C12H18N2O5/c1-6(2)7-4-14(12(18)13-11(7)17)10-3-8(16)9(5-15)19-10/h4,6,8-10,15-16H,3,5H2,1-2H3,(H,13,17,18)/t8-,9+,10+/m0/s1

InChI key: InChIKey=PHUUXVYXSRZACJ-IVZWLZJFSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C(C)C)C(=O)N1

Synonyms:

• 1-(2-deoxypentofuranosyl)-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
• 2'-Deoxy-5-Propan-2-Yluridine
• 2'-Deoxy-5-isopropyluridine
• 2′-Deoxy-5-(1-methylethyl)uridine
• 5-Isopropyl-2'-deoxyuridine
• 5-Isopropyldeoxyuridine
• Epervudina
• Epervudina [INN-Spanish]
• Epervudine [INN]
• Epervudinum
• Epervudinum [INN-Latin]
• Unii-3G05Ph9Fas
• Uridine, 2′-deoxy-5-(1-methylethyl)-
• Epervudine
• Epervudine

5-Isopropyl-2''-deoxyuridine

CAS: 60136-25-6

Ref: 7W-GC3654

5-Isopropyl-2'-deoxyuridine

Controlled Product

CAS: 60136-25-6

Applications 5-Isopropyl-2'-deoxyuridine (IP5dU) was recently recognized as a clinical useful antiherpetic (HSV-1) agent.
References Levin, R., et al.: Cancer, 72, 2895 (1993), Cook, G., et al.: Chem. Biol., 6, 451 (1999),

Formula: C₁₂H₁₈N₂O₅

Color and Shape: Neat

Molecular weight: 270.28

Ref: TR-I824410

5-Isopropyl-2'-deoxyuridine

CAS: 60136-25-6

5-Isopropyl-2'-deoxyuridine is a nucleoside analog that is used in the treatment of inflammatory bowel disease. It has been shown to be effective in the treatment of Crohn's disease, ulcerative colitis, and indeterminate colitis. 5-Isopropyl-2'-deoxyuridine inhibits bacterial growth by inhibiting RNA synthesis, which leads to cell death. This drug also inhibits the production of inflammatory mediators such as prostaglandins and leukotrienes that are released from cells infected with bacteria. 5-Isopropyl-2'-deoxyuridine is converted into an active form by hydrolysis or oxidation followed by phosphorylation. This drug binds to the 5' end of bacterial DNA and prevents the formation of hydrogen bonds between adjacent bases, causing strand breakage.

Formula: C₁₂H₁₈N₂O₅

Purity: Min. 95%

Molecular weight: 270.28 g/mol

Ref: 3D-NI16765