CAS 60153-49-3

3-(Methylnitrosoamino)propanenitrile

Description:

3-(Methylnitrosoamino)propanenitrile, with the CAS number 60153-49-3, is a chemical compound that belongs to the class of nitrosamines, which are known for their potential carcinogenic properties. This substance features a propanenitrile backbone, which includes a cyano group (-C≡N) attached to a three-carbon chain, along with a methylnitrosoamino group. The presence of the nitroso group (-NO) is significant, as it can participate in various chemical reactions, including those that lead to the formation of DNA adducts, which are implicated in mutagenesis and cancer development. The compound is typically a colorless to pale yellow liquid or solid, depending on its purity and specific conditions. It is important to handle this substance with care due to its toxicological profile, and it is often studied in the context of its effects on biological systems and its role in environmental chemistry. Proper safety measures should be taken when working with this compound in laboratory settings.

Formula: C₄H₇N₃O

InChI: InChI=1S/C4H7N3O/c1-7(6-8)4-2-3-5/h2,4H2,1H3

InChI key: InChIKey=HZDLDFBKYBGNHG-UHFFFAOYSA-N

SMILES: N(CCC#N)(N=O)C

Synonyms:

• 3-(Methylnitrosamino)Propionitrile
• 3-(Methylnitrosoamino)propanenitrile
• 3-(N-Nitrosomethylamino)propionitrile
• N-(2-Cyanoethyl)-N-methylnitrosamine
• Propanenitrile, 3-(Methylnitrosoamino)-
• Propionitrile, 3-(methylnitrosamino)-

3-(Methylnitrosoamino) Propanenitrile

CAS: 60153-49-3

Formula: C₄H₇N₃O

Molecular weight: 113.12

Ref: 4Z-I-1019

3-(Methylnitrosamino)propionitrile

Controlled Product

CAS: 60153-49-3

Applications 3-(Methylnitrosamino)propionitrile (MNPN) was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen.
References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),

Formula: C₄H₇N₃O

Color and Shape: Light Yellow

Molecular weight: 113.12

Ref: TR-M325715

3-(Methylnitrosamino)propionitrile-d7

Controlled Product

CAS: 60153-49-3

Applications Labelled 3-(Methylnitrosamino)propionitrile (MNPN) (M325715). It was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen.
References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),

Formula: C₄D₇N₃O

Color and Shape: Neat

Molecular weight: 120.16

Ref: TR-M325717

3-(Methylnitrosamino)propionitrile

CAS: 60153-49-3

3-(Methylnitrosamino)propionitrile (NNK) is a potent, but toxic, carcinogen that has been shown to be one of the major causes of lung cancer in animals. It is metabolized to 3-aminobenzamide and N-nitrosodimethylamine (NDMA) by cytochrome P450 enzymes. These metabolites are then further converted into reactive species that bind covalently with DNA, leading to mutations and ultimately cancer. The activation of NNK can be prevented by inhibiting the enzyme hydrolysis or by blocking the synthesis of the reactive metabolites.

Formula: C₄H₇N₃O

Purity: Area-% Min. 95 Area-%

Molecular weight: 113.12 g/mol

Ref: 3D-FM25902