CAS 60223-75-8

15-[5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylic acid

Description:

The chemical substance with the name "15-[5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylic acid" and CAS number "60223-75-8" is a complex organic molecule characterized by its intricate structure, which includes multiple functional groups such as hydroxyl (-OH), methoxy (-OCH3), and carboxylic acid (-COOH) groups. This compound is likely to exhibit significant biological activity, potentially related to its structural features that resemble alkaloids, which are known for their pharmacological properties. The presence of multiple stereocenters suggests that it may exist in different stereoisomeric forms, which can influence its biological interactions and efficacy. Additionally, the compound's solubility and stability may vary depending on the pH and solvent conditions, making it important for applications in medicinal chemistry and drug development. Overall, this substance represents a class of compounds that may have therapeutic potential, warranting further investigation into its properties and applications.

Formula: C₄₃H₅₄N₄O₈

InChI: InChI=1/C43H54N4O8/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-46(23-25)24-39)26-11-8-9-12-30(26)44-33)29-19-28-31(20-32(29)54-4)45(3)35-41(28)15-18-47-16-10-14-40(7-2,34(41)47)36(48)43(35,53)37(49)50/h8-12,14,19-20,25,34-36,44,48,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H,49,50)

SMILES: CCC1(CC2CC(c3cc4c(cc3OC)N(C)C3C54CCN4CC=CC(CC)(C54)C(C3(C(=O)O)O)O)(c3c(CCN(C2)C1)c1ccccc1[nH]3)C(=O)OC)O

O4-Desacetyl Vinblastinic Acid

CAS: 60223-75-8

Stability Temperature sensitive
Applications O4-Desacetyl Vinblastinic Acid is an impurity of Vinblastine Sulfate (V314000), an Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
References Lu, C., et al.: Cancer Research, 39, 3575 (1979), Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992),

Formula: C₄₃H₅₄N₄O₈

Purity: >90%

Color and Shape: Neat

Molecular weight: 754.91

Ref: TR-D281895

O4-Desacetyl vinblastinic acid

Controlled Product

CAS: 60223-75-8

O4-Desacetyl vinblastinic acid is a medicinal compound that is an analog of vinblastine, a natural product derived from the Madagascar periwinkle. It is an inhibitor of kinases and has been shown to induce apoptosis in cancer cells. O4-Desacetyl vinblastinic acid has potent anticancer activity against human tumors and has been identified as a potential candidate for the development of new cancer therapies. This compound inhibits protein synthesis and disrupts microtubule assembly, leading to cell death in cancer cells. O4-Desacetyl vinblastinic acid is excreted in urine and has been used as a diagnostic marker for certain types of cancers. It is considered a promising lead compound for the development of novel kinase inhibitors with therapeutic potential against cancer.

Formula: C₄₃H₅₄N₄O₈

Purity: Min. 95%

Molecular weight: 754.9 g/mol

Ref: 3D-KCA22375